P70665 · SIAE_MOUSE
- ProteinSialate O-acetylesterase
- GeneSiae
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids541 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
Catalytic activity
- H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate
Activity regulation
Inhibited by diisopropyl fluorophosphate and diethyl-P-nitrophenyl phosphate.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | lysosome | |
Molecular Function | sialate 4-O-acetylesterase activity | |
Molecular Function | sialate 9-O-acetylesterase activity | |
Molecular Function | sialate O-acetylesterase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | regulation of immune system process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSialate O-acetylesterase
- EC number
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP70665
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MVSPGPVFGIVLLIIARVSRSAG | ||||||
Chain | PRO_0000022714 | 24-275 | Sialate O-acetylesterase small subunit | |||
Sequence: IGFRFASYIDNYMVLQKEPSGAVIWGFGTPGATVTVTLCQGQETIMKKVTSVKEPSNTWMVVLDPMKPGGPFEVMAQQTLGTMNFTLRVHDVLFGDVWLCSGQSNMQMTVSQIFNASKELSDTAAYQSVRIFSVSLIQSEEELDDLTEVDLSWSKPTAGNLGHGNFTYMSAVCWLFGRYLYDTLQYPIGLVSSSWGGTYIEVWSSRRTLKACGVPNTRDERVGQPEIKPMRNECNSEESSCPFRVVPSVRVT | ||||||
Glycosylation | 107 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 138 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 188 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Chain | PRO_0000022715 | 276-541 | Sialate O-acetylesterase large subunit | |||
Sequence: GPTRHSVLWNAMIHPLQNMTLKGVVWYQGESNADYNRDLYTCMFPELIEDWRQTFHYGSQGQTDRFFPFGFVQLSSYMLKNSSDYGFPEIRWHQTADFGHVPNPKMPNTFMAVAIDLCDRDSPFGSIHPRDKQTVAYRLHLGARAVAYGEKNLTFQGPLPKKIELLASNGLLNLTYDQEIQVQMQDNKTFEISCCSDRHCKWLPAPVNTFSTQTLILDLNACLGTVVAVRYAWTTWPCEYKQCAVYHTSSMLPAPPFIAQISHRGI | ||||||
Glycosylation | 293 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 356 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 427 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 448 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 462 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
The two subunits are derived from a single precursor by proteolytic cleavage.
The lysosomal isoform is glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 3 isoforms produced by Alternative splicing.
P70665-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsLse
- Length541
- Mass (Da)60,775
- Last updated2006-05-30 v3
- Checksum944936C45C4A2E6B
P70665-2
- Name2
- SynonymsCse
- Differences from canonical
- 1-97: Missing
P70665-3
- Name3
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1N9M4K1 | A0A1N9M4K1_MOUSE | Siae | 469 | ||
A0A1L1SU77 | A0A1L1SU77_MOUSE | Siae | 506 | ||
A0A1L1SQX0 | A0A1L1SQX0_MOUSE | Siae | 111 | ||
A0A1L1SQF7 | A0A1L1SQF7_MOUSE | Siae | 134 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_004077 | 1-97 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 114 | in Ref. 4; BAE37942 | ||||
Sequence: D → N | ||||||
Sequence conflict | 160 | in Ref. 2; AAB07813 and 5; AAH07136 | ||||
Sequence: I → T | ||||||
Sequence conflict | 349 | in Ref. 4; BAC26026 | ||||
Sequence: L → Q | ||||||
Alternative sequence | VSP_018996 | 349-390 | in isoform 3 | |||
Sequence: LSSYMLKNSSDYGFPEIRWHQTADFGHVPNPKMPNTFMAVAI → VCIQRIHIQCLEFMGLCGECGLCTCLYWDLQPNICPNSMSWR | ||||||
Sequence conflict | 373 | in Ref. 4; BAC29164 | ||||
Sequence: F → L | ||||||
Sequence conflict | 379 | in Ref. 5; AAH07136 | ||||
Sequence: P → L | ||||||
Alternative sequence | VSP_018997 | 391-541 | in isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U61183 EMBL· GenBank· DDBJ | AAC52880.1 EMBL· GenBank· DDBJ | mRNA | ||
X98625 EMBL· GenBank· DDBJ | CAA67214.1 EMBL· GenBank· DDBJ | mRNA | ||
U40408 EMBL· GenBank· DDBJ | AAB07813.1 EMBL· GenBank· DDBJ | mRNA | ||
AF156856 EMBL· GenBank· DDBJ | AAD55976.1 EMBL· GenBank· DDBJ | mRNA | ||
AK028598 EMBL· GenBank· DDBJ | BAC26026.1 EMBL· GenBank· DDBJ | mRNA | ||
AK028656 EMBL· GenBank· DDBJ | BAC26049.1 EMBL· GenBank· DDBJ | mRNA | ||
AK033980 EMBL· GenBank· DDBJ | BAC28536.1 EMBL· GenBank· DDBJ | mRNA | ||
AK035715 EMBL· GenBank· DDBJ | BAC29164.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK043392 EMBL· GenBank· DDBJ | BAC31534.1 EMBL· GenBank· DDBJ | mRNA | ||
AK164852 EMBL· GenBank· DDBJ | BAE37942.1 EMBL· GenBank· DDBJ | mRNA | ||
AK167103 EMBL· GenBank· DDBJ | BAE39252.1 EMBL· GenBank· DDBJ | mRNA | ||
BC007136 EMBL· GenBank· DDBJ | AAH07136.1 EMBL· GenBank· DDBJ | mRNA |