P70475 · MYT1L_RAT

  • Protein
    Myelin transcription factor 1-like protein
  • Gene
    Myt1l
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor that plays a key role in neuronal differentiation (PubMed:9373037).
Acts by specifically repressing expression of non-neuronal genes during neuron differentiation (By similarity).
In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (By similarity).
Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (By similarity).
The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity).
Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (By similarity).
The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (By similarity).

Features

Showing features for binding site.

111871002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site31Zn2+ 1 (UniProtKB | ChEBI)
Binding site36Zn2+ 1 (UniProtKB | ChEBI)
Binding site49Zn2+ 1 (UniProtKB | ChEBI)
Binding site55Zn2+ 1 (UniProtKB | ChEBI)
Binding site505Zn2+ 2 (UniProtKB | ChEBI)
Binding site510Zn2+ 2 (UniProtKB | ChEBI)
Binding site523Zn2+ 2 (UniProtKB | ChEBI)
Binding site529Zn2+ 2 (UniProtKB | ChEBI)
Binding site549Zn2+ 3 (UniProtKB | ChEBI)
Binding site554Zn2+ 3 (UniProtKB | ChEBI)
Binding site567Zn2+ 3 (UniProtKB | ChEBI)
Binding site573Zn2+ 3 (UniProtKB | ChEBI)
Binding site904Zn2+ 4 (UniProtKB | ChEBI)
Binding site909Zn2+ 4 (UniProtKB | ChEBI)
Binding site922Zn2+ 4 (UniProtKB | ChEBI)
Binding site928Zn2+ 4 (UniProtKB | ChEBI)
Binding site953Zn2+ 5 (UniProtKB | ChEBI)
Binding site958Zn2+ 5 (UniProtKB | ChEBI)
Binding site971Zn2+ 5 (UniProtKB | ChEBI)
Binding site977Zn2+ 5 (UniProtKB | ChEBI)
Binding site1006Zn2+ 6 (UniProtKB | ChEBI)
Binding site1011Zn2+ 6 (UniProtKB | ChEBI)
Binding site1024Zn2+ 6 (UniProtKB | ChEBI)
Binding site1030Zn2+ 6 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome
Cellular Componentnucleus
Molecular Functioncobalt ion binding
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionmetal ion sequestering activity
Molecular Functionretinoic acid-responsive element binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functiontranscription coactivator activity
Molecular Functionzinc ion binding
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnervous system development
Biological Processneuron development
Biological Processneuron differentiation
Biological Processneuron fate commitment
Biological Processneuron fate specification
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Myelin transcription factor 1-like protein
  • Short names
    MyT1-L; MyT1L
  • Alternative names
    • Neural zinc finger factor 1
      (NZF-1
      )

Gene names

    • Name
      Myt1l
    • Synonyms
      Nzf1

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P70475
  • Secondary accessions
    • D4A9W2
    • P70589

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Chromosome
Note: Preferentially binds to DNA binding sites that are in an open chromatin configuration.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000966751-1187Myelin transcription factor 1-like protein
Modified residue251Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Brain, testis and pituitary gland. Expression is higher in the brain than in the testis and pituitary gland. Highest level expression seen in the developing CNS.

Developmental stage

Detected at 11.5 dpc and expression is seen throughout the proliferating cortex neuroepithelium, developing medulla, and spinal cord. At 12.5 dpc found in the nasal epithelium and at 13.5 dpc detected in the trigeminal ganglia, dorsal root ganglia and the ganglion cell layer of the retina. At 14 dpc to 15 dpc, expressed at high levels in the brain and spinal cord and then levels subsequently decrease.

Interaction

Subunit

Interacts with SIN3B.

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, zinc finger, coiled coil.

TypeIDPosition(s)Description
Compositional bias1-17Basic and acidic residues
Region1-20Disordered
Zinc finger22-65CCHHC-type 1
Region56-178Disordered
Compositional bias90-172Acidic residues
Region221-248Disordered
Compositional bias343-359Polar residues
Region343-422Disordered
Compositional bias400-422Basic and acidic residues
Compositional bias450-506Basic and acidic residues
Region450-509Disordered
Zinc finger496-539CCHHC-type 2
Zinc finger540-583CCHHC-type 3
Region684-708Disordered
Zinc finger895-938CCHHC-type 4
Zinc finger944-987CCHHC-type 5
Zinc finger997-1040CCHHC-type 6
Coiled coil1055-1131

Sequence similarities

Belongs to the MYT1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

P70475-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,187
  • Mass (Da)
    132,926
  • Last updated
    2017-06-07 v3
  • Checksum
    10B2616415195DD1
MDVDAEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECYESDGTEDMDDKEEDDDEEFSEDNDEQGDDDDEDEVDREDEEEIEEEDDEDDEDDDDGDDVEEEEDDDDEEEEEEEEEEENEDHQMSCTRIMQDPEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENISDRSYAEGMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQDRSQPPNMSVRQHVRQEDDFPGRTPDRSYSDMMNLMRLEEQLSPRSRTFSSCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMDAGRRDNLRSYEDQSPRQLAGEDRKSKSSDSHVKKPYYDPSRTEKRESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHENVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSNQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKNASPSSSTTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCTARNPDMEVDENGTLDLSMNKQRPRDSCCPVLTPLEPMSPQQQAVMSSRCFQLSEGDCWDLPVDYTKMKPRRVDEEDPKEITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQVTITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV

P70475-2

P70475-3

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6A7T9A0A8I6A7T9_RATMyt1l328
A0A5H1ZRT6A0A5H1ZRT6_RATMyt1l1187
A0A8I6A056A0A8I6A056_RATMyt1l1164
F1M8L4F1M8L4_RATMyt1l1181

Sequence caution

The sequence AABR07063792 differs from that shown. Reason: Erroneous gene model prediction
The sequence AABR07063793 differs from that shown. Reason: Erroneous gene model prediction
The sequence AABR07063794 differs from that shown. Reason: Erroneous gene model prediction
The sequence AABR07063795 differs from that shown. Reason: Erroneous gene model prediction
The sequence AABR07063796 differs from that shown. Reason: Erroneous gene model prediction
The sequence AABR07063797 differs from that shown. Reason: Erroneous gene model prediction
The sequence AAC52728.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-17Basic and acidic residues
Sequence conflict39in Ref. 1; AAC52728
Compositional bias90-172Acidic residues
Sequence conflict226in Ref. 1; AAC52728
Sequence conflict237-239in Ref. 1; AAC52728
Compositional bias343-359Polar residues
Compositional bias400-422Basic and acidic residues
Sequence conflict415in Ref. 1; AAC52728
Compositional bias450-506Basic and acidic residues
Sequence conflict517in Ref. 1; AAC52728
Sequence conflict561in Ref. 3; AAB40718
Sequence conflict804in Ref. 3; AAB40718
Sequence conflict918in Ref. 3; AAB40718
Sequence conflict1019in Ref. 3; AAB40718
Sequence conflict1092-1098in Ref. 3; AAB40718

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U48809
EMBL· GenBank· DDBJ
AAC52728.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AABR07063792
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07063793
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07063794
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07063795
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07063796
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07063797
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
U67081
EMBL· GenBank· DDBJ
AAB40718.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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