P70408 · CAD10_MOUSE
- ProteinCadherin-10
- GeneCdh10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids788 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Variants
Variant ID(s) | Position(s) | Change | Description | Clinical significance | Provenance | ||
---|---|---|---|---|---|---|---|
rs3389356642 | 24 | L>V | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated - low confidence (0.45) Somatic: No Accession: NC_000081.7:g.18899744T>G Codon: TTA/GTA Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18899744T>G Locations: - p.Leu24Val (Ensembl:ENSMUST00000166873) - c.70T>G (Ensembl:ENSMUST00000166873) - p.Leu24Val (Ensembl:ENSMUST00000040562) - c.70T>G (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs250521368 | 25 | T>M | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated - low confidence (0.26) Somatic: No Accession: NC_000081.7:g.18899748C>T Codon: ACG/ATG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18899748C>T Locations: - p.Thr25Met (Ensembl:ENSMUST00000166873) - c.74C>T (Ensembl:ENSMUST00000166873) - p.Thr25Met (Ensembl:ENSMUST00000040562) - c.74C>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389364774 | 35 | M>V | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated (0.31) Somatic: No Accession: NC_000081.7:g.18899777A>G Codon: ATG/GTG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18899777A>G Locations: - p.Met35Val (Ensembl:ENSMUST00000166873) - c.103A>G (Ensembl:ENSMUST00000166873) - p.Met35Val (Ensembl:ENSMUST00000040562) - c.103A>G (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs250658670 | 135 | R>K | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated (0.62) Somatic: No Accession: NC_000081.7:g.18964243G>A Codon: AGA/AAA Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18964243G>A Locations: - p.Arg135Lys (Ensembl:ENSMUST00000166873) - c.404G>A (Ensembl:ENSMUST00000166873) - p.Arg135Lys (Ensembl:ENSMUST00000040562) - c.404G>A (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389317216 | 258 | T>S | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated (0.07) Somatic: No Accession: NC_000081.7:g.18966953A>T Codon: ACT/TCT Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18966953A>T Locations: - p.Thr258Ser (Ensembl:ENSMUST00000166873) - c.772A>T (Ensembl:ENSMUST00000166873) - p.Thr258Ser (Ensembl:ENSMUST00000040562) - c.772A>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389360293 | 282 | S>Y | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0.01) Somatic: No Accession: NC_000081.7:g.18985182C>A Codon: TCT/TAT Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18985182C>A Locations: - p.Ser282Tyr (Ensembl:ENSMUST00000166873) - c.845C>A (Ensembl:ENSMUST00000166873) - p.Ser282Tyr (Ensembl:ENSMUST00000040562) - c.845C>A (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389336821 | 301 | N>I | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.18985239A>T Codon: AAT/ATT Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18985239A>T Locations: - p.Asn301Ile (Ensembl:ENSMUST00000166873) - c.902A>T (Ensembl:ENSMUST00000166873) - p.Asn301Ile (Ensembl:ENSMUST00000040562) - c.902A>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389345095 | 378 | V>A | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated (0.06) Somatic: No Accession: NC_000081.7:g.18986903T>C Codon: GTG/GCG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18986903T>C Locations: - p.Val378Ala (Ensembl:ENSMUST00000166873) - c.1133T>C (Ensembl:ENSMUST00000166873) - p.Val378Ala (Ensembl:ENSMUST00000040562) - c.1133T>C (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs230787678 | 378 | V>L | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.18986902G>T Codon: GTG/TTG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18986902G>T Locations: - p.Val378Leu (Ensembl:ENSMUST00000166873) - c.1132G>T (Ensembl:ENSMUST00000166873) - p.Val378Leu (Ensembl:ENSMUST00000040562) - c.1132G>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs230787678 | 378 | V>M | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0.01) Somatic: No Accession: NC_000081.7:g.18986902G>A Codon: GTG/ATG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18986902G>A Locations: - p.Val378Met (Ensembl:ENSMUST00000166873) - c.1132G>A (Ensembl:ENSMUST00000166873) - p.Val378Met (Ensembl:ENSMUST00000040562) - c.1132G>A (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389325851 | 423 | D>N | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0.01) Somatic: No Accession: NC_000081.7:g.18992009G>A Codon: GAT/AAT Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.18992009G>A Locations: - p.Asp423Asn (Ensembl:ENSMUST00000166873) - c.1267G>A (Ensembl:ENSMUST00000166873) - p.Asp423Asn (Ensembl:ENSMUST00000040562) - c.1267G>A (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389345127 | 515 | K>* | EVA | ||||
Consequence: stop gained Somatic: No Accession: NC_000081.7:g.19007665A>T Codon: AAA/TAA Consequence type: stop gained Cytogenetic band: 15q Genomic location: NC_000081.7:g.19007665A>T Locations: - p.Lys515Ter (Ensembl:ENSMUST00000166873) - c.1543A>T (Ensembl:ENSMUST00000166873) - p.Lys515Ter (Ensembl:ENSMUST00000040562) - c.1543A>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3405825340 | 542 | D>R | EVA | ||||
Consequence: stop gained Somatic: No Accession: NC_000081.7:g.19007744_19007745insGCGATGTCCATAGCAAG Codon: GAA/GAGCGATGTCCATAGCAAGA Consequence type: stop gained Cytogenetic band: 15q Genomic location: NC_000081.7:g.19007744_19007745insGCGATGTCCATAGCAAG Locations: - p.Asp542ArgfsTer4 (Ensembl:ENSMUST00000166873) - c.1622_1623insGCGATGTCCATAGCAAG (Ensembl:ENSMUST00000166873) - p.Asp542ArgfsTer4 (Ensembl:ENSMUST00000040562) - c.1622_1623insGCGATGTCCATAGCAAG (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389317218 | 585 | R>S | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.19011071C>A Codon: CGT/AGT Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19011071C>A Locations: - p.Arg585Ser (Ensembl:ENSMUST00000166873) - c.1753C>A (Ensembl:ENSMUST00000166873) - p.Arg585Ser (Ensembl:ENSMUST00000040562) - c.1753C>A (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389364748 | 586 | V>M | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.19011074G>A Codon: GTG/ATG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19011074G>A Locations: - p.Val586Met (Ensembl:ENSMUST00000166873) - c.1756G>A (Ensembl:ENSMUST00000166873) - p.Val586Met (Ensembl:ENSMUST00000040562) - c.1756G>A (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs47021013 | 598 | C>W | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.19011112T>G Codon: TGT/TGG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19011112T>G Locations: - p.Cys598Trp (Ensembl:ENSMUST00000166873) - c.1794T>G (Ensembl:ENSMUST00000166873) - p.Cys598Trp (Ensembl:ENSMUST00000040562) - c.1794T>G (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389364753 | 641 | E>D | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated (0.08) Somatic: No Accession: NC_000081.7:g.19013324G>C Codon: GAG/GAC Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013324G>C Locations: - p.Glu641Asp (Ensembl:ENSMUST00000166873) - c.1923G>C (Ensembl:ENSMUST00000166873) - p.Glu641Asp (Ensembl:ENSMUST00000040562) - c.1923G>C (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389336784 | 652 | D>E | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated (0.38) Somatic: No Accession: NC_000081.7:g.19013357C>A Codon: GAC/GAA Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013357C>A Locations: - p.Asp652Glu (Ensembl:ENSMUST00000166873) - c.1956C>A (Ensembl:ENSMUST00000166873) - p.Asp652Glu (Ensembl:ENSMUST00000040562) - c.1956C>A (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389307389 | 685 | K>E | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.19013454A>G Codon: AAG/GAG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013454A>G Locations: - p.Lys685Glu (Ensembl:ENSMUST00000166873) - c.2053A>G (Ensembl:ENSMUST00000166873) - p.Lys685Glu (Ensembl:ENSMUST00000040562) - c.2053A>G (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389356625 | 686 | L>F | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated (0.37) Somatic: No Accession: NC_000081.7:g.19013457C>T Codon: CTC/TTC Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013457C>T Locations: - p.Leu686Phe (Ensembl:ENSMUST00000166873) - c.2056C>T (Ensembl:ENSMUST00000166873) - p.Leu686Phe (Ensembl:ENSMUST00000040562) - c.2056C>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389360290 | 707 | N>T | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0.01) Somatic: No Accession: NC_000081.7:g.19013521A>C Codon: AAC/ACC Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013521A>C Locations: - p.Asn707Thr (Ensembl:ENSMUST00000166873) - c.2120A>C (Ensembl:ENSMUST00000166873) - p.Asn707Thr (Ensembl:ENSMUST00000040562) - c.2120A>C (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389352752 | 716 | E>* | EVA | ||||
Consequence: stop gained Somatic: No Accession: NC_000081.7:g.19013547G>T Codon: GAG/TAG Consequence type: stop gained Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013547G>T Locations: - p.Glu716Ter (Ensembl:ENSMUST00000166873) - c.2146G>T (Ensembl:ENSMUST00000166873) - p.Glu716Ter (Ensembl:ENSMUST00000040562) - c.2146G>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389336805 | 731 | D>H | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.19013592G>C Codon: GAC/CAC Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013592G>C Locations: - p.Asp731His (Ensembl:ENSMUST00000166873) - c.2191G>C (Ensembl:ENSMUST00000166873) - p.Asp731His (Ensembl:ENSMUST00000040562) - c.2191G>C (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389349832 | 733 | L>P | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.19013599T>C Codon: CTG/CCG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013599T>C Locations: - p.Leu733Pro (Ensembl:ENSMUST00000166873) - c.2198T>C (Ensembl:ENSMUST00000166873) - p.Leu733Pro (Ensembl:ENSMUST00000040562) - c.2198T>C (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3405821656 | 745 | A>S | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.19013634G>T Codon: GCC/TCC Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013634G>T Locations: - p.Ala745Ser (Ensembl:ENSMUST00000166873) - c.2233G>T (Ensembl:ENSMUST00000166873) - p.Ala745Ser (Ensembl:ENSMUST00000040562) - c.2233G>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389364726 | 759 | D>A | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0.01) Somatic: No Accession: NC_000081.7:g.19013677A>C Codon: GAC/GCC Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013677A>C Locations: - p.Asp759Ala (Ensembl:ENSMUST00000166873) - c.2276A>C (Ensembl:ENSMUST00000166873) - p.Asp759Ala (Ensembl:ENSMUST00000040562) - c.2276A>C (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389275247 | 769 | G>E | EVA | ||||
Consequence: missense Predictions: - SIFT: deleterious (0) Somatic: No Accession: NC_000081.7:g.19013707G>A Codon: GGA/GAA Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013707G>A Locations: - p.Gly769Glu (Ensembl:ENSMUST00000166873) - c.2306G>A (Ensembl:ENSMUST00000166873) - p.Gly769Glu (Ensembl:ENSMUST00000040562) - c.2306G>A (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389364813 | 778 | M>L | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated (0.45) Somatic: No Accession: NC_000081.7:g.19013733A>T Codon: ATG/TTG Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013733A>T Locations: - p.Met778Leu (Ensembl:ENSMUST00000166873) - c.2332A>T (Ensembl:ENSMUST00000166873) - p.Met778Leu (Ensembl:ENSMUST00000040562) - c.2332A>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: | |||||||
rs3389348683 | 782 | G>V | EVA | ||||
Consequence: missense Predictions: - SIFT: tolerated (0.22) Somatic: No Accession: NC_000081.7:g.19013746G>T Codon: GGC/GTC Consequence type: missense Cytogenetic band: 15q Genomic location: NC_000081.7:g.19013746G>T Locations: - p.Gly782Val (Ensembl:ENSMUST00000166873) - c.2345G>T (Ensembl:ENSMUST00000166873) - p.Gly782Val (Ensembl:ENSMUST00000040562) - c.2345G>T (Ensembl:ENSMUST00000040562) Source type: large scale study Cross-references: |