P70408 · CAD10_MOUSE

  • Protein
    Cadherin-10
  • Gene
    Cdh10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadherens junction
Cellular Componentcatenin complex
Cellular ComponentGABA-ergic synapse
Cellular Componentglutamatergic synapse
Cellular Componentpostsynaptic specialization membrane
Cellular Componentpresynaptic active zone membrane
Cellular Componentsynapse
Molecular Functionbeta-catenin binding
Molecular Functioncadherin binding
Molecular Functioncalcium ion binding
Biological Processadherens junction organization
Biological Processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processcell migration
Biological Processcell morphogenesis
Biological Processcell-cell adhesion mediated by cadherin
Biological Processcell-cell junction assembly
Biological Processhomophilic cell adhesion via plasma membrane adhesion molecules
Biological Processsynaptic membrane adhesion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cadherin-10
  • Alternative names
    • T2-cadherin

Gene names

    • Name
      Cdh10

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • CBA/J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P70408
  • Secondary accessions
    • Q3UUB3
    • Q80WS7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain23-613Extracellular
Transmembrane614-634Helical
Topological domain635-788Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, chain, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-22
PropeptidePRO_000026966223-54
ChainPRO_000012664655-788Cadherin-10
Glycosylation256N-linked (GlcNAc...) asparagine
Glycosylation456N-linked (GlcNAc...) asparagine
Glycosylation534N-linked (GlcNAc...) asparagine
Modified residue784Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed at all stages of testicular development with highest levels found in fetal gonad.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain56-160Cadherin 1
Domain161-269Cadherin 2
Domain270-384Cadherin 3
Domain385-489Cadherin 4
Domain489-603Cadherin 5

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    788
  • Mass (Da)
    88,312
  • Last updated
    2011-07-27 v3
  • Checksum
    4066D21DBB038AE1
MTIYQFLRLFVLWACLPHFCCPELTFRRTPGIQQMTAESRAPRSDGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENKEQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAVGSVKATDADTGKNAEVDYRIIDGDGTDMFDIITEKDTQEGIITVKKPLDYENRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSTSSPIRFTLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKETTRVSVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEGNDSVAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H3BKV8H3BKV8_MOUSECdh10419

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict142in Ref. 2; AAH52056/AAH62962
Sequence conflict518-525in Ref. 3; AAB87708
Sequence conflict549in Ref. 3; AAB87708
Sequence conflict607-610in Ref. 3; AAB87708
Sequence conflict635-639in Ref. 3; AAB87708
Sequence conflict699in Ref. 3; AAB87708
Sequence conflict706in Ref. 3; AAB87708
Sequence conflict773in Ref. 3; AAB87708
Sequence conflict788in Ref. 3; AAB87708

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK138606
EMBL· GenBank· DDBJ
BAE23714.1
EMBL· GenBank· DDBJ
mRNA
BC052056
EMBL· GenBank· DDBJ
AAH52056.1
EMBL· GenBank· DDBJ
mRNA
BC062962
EMBL· GenBank· DDBJ
AAH62962.1
EMBL· GenBank· DDBJ
mRNA
U69137
EMBL· GenBank· DDBJ
AAB87708.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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