P70348 · GCM1_MOUSE

  • Protein
    Chorion-specific transcription factor GCMa
  • Gene
    Gcm1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor that is necessary for placental development (PubMed:8962155).
Involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (By similarity).

Features

Showing features for dna binding, binding site.

143650100150200250300350400
TypeIDPosition(s)Description
DNA binding14-169GCM
Binding site76Zn2+ 1 (UniProtKB | ChEBI)
Binding site82Zn2+ 2 (UniProtKB | ChEBI)
Binding site86Zn2+ 2 (UniProtKB | ChEBI)
Binding site113Zn2+ 2 (UniProtKB | ChEBI)
Binding site116Zn2+ 2 (UniProtKB | ChEBI)
Binding site125Zn2+ 1 (UniProtKB | ChEBI)
Binding site152Zn2+ 1 (UniProtKB | ChEBI)
Binding site154Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionhistone deacetylase binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processastrocyte fate commitment
Biological Processbranching involved in labyrinthine layer morphogenesis
Biological Processcell differentiation involved in embryonic placenta development
Biological Processgliogenesis
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of syncytium formation by plasma membrane fusion
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of cell differentiation involved in embryonic placenta development
Biological Processregulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II
Biological Processsyncytium formation by plasma membrane fusion
Biological Processtranscription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Chorion-specific transcription factor GCMa
  • Alternative names
    • GCM motif protein 1 (mGCM1; mGCMa)
    • Glial cells missing homolog 1

Gene names

    • Name
      Gcm1
    • Synonyms
      Gcma

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P70348
  • Secondary accessions
    • O09103

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis63No effect on DNA binding.
Mutagenesis63Slight decrease of DNA binding.
Mutagenesis65Strong decrease of DNA binding.
Mutagenesis65Loss of DNA binding.
Mutagenesis74Loss of DNA binding.
Mutagenesis76Loss of transcription activation.
Mutagenesis82Loss of transcription activation.
Mutagenesis113Loss of transcription activation.
Mutagenesis125Loss of transcription activation.
Mutagenesis152Loss of transcription activation.
Mutagenesis154Loss of transcription activation.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 34 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001266481-436Chorion-specific transcription factor GCMa

Post-translational modification

Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Placenta specific.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    436
  • Mass (Da)
    49,589
  • Last updated
    1997-02-01 v1
  • Checksum
    99F4E441800582DB
MELDDFDPEDKEILSWDINDVKLPQNVKTTDWFQEWPDSYVKHIYSSDDRNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICDKARQKQQRKSCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPRPETKLEAEARRAMKKVHMASASNSLRMKGRPAAKALPAEIPSQGSLPLTWSFQEGVQLPGTYSTPLIANAPQQNSLNDCLSFPKSYDLGGSTELEDPTSTLDSMKFYERCKFSSSRIYGSEEQFQPPVPGTYGDYEDLQTWNKNVALGRNPSDDIYYPAYPLPVASWPYDYFPSQNSLEHLPQQVPSEPPAAQPGCHPLWSNPGGEPYEEKVSVDLSSYVPSLTYHPPQQDPFLLTYGSPTQQQHALPGKSNRWDFDEEMACMGLDHFNNEMLLNFCSLR

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict211in Ref. 2; BAA13650
Sequence conflict230in Ref. 2; BAA13650
Sequence conflict241in Ref. 2; BAA13650
Sequence conflict413in Ref. 2; BAA13650

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U59876
EMBL· GenBank· DDBJ
AAC52822.1
EMBL· GenBank· DDBJ
mRNA
D88612
EMBL· GenBank· DDBJ
BAA13650.1
EMBL· GenBank· DDBJ
mRNA
BC066866
EMBL· GenBank· DDBJ
AAH66866.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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