P70348 · GCM1_MOUSE
- ProteinChorion-specific transcription factor GCMa
- GeneGcm1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids436 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor that is necessary for placental development (PubMed:8962155).
Involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (By similarity).
Involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (By similarity).
Features
Showing features for dna binding, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 14-169 | GCM | ||||
Sequence: LSWDINDVKLPQNVKTTDWFQEWPDSYVKHIYSSDDRNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICDKARQKQQRKSCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPRPETKLEAEARRAM | ||||||
Binding site | 76 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 82 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 86 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 113 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 116 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 125 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 152 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 154 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameChorion-specific transcription factor GCMa
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP70348
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 63 | No effect on DNA binding. | ||||
Sequence: N → A | ||||||
Mutagenesis | 63 | Slight decrease of DNA binding. | ||||
Sequence: N → Q | ||||||
Mutagenesis | 65 | Strong decrease of DNA binding. | ||||
Sequence: N → A | ||||||
Mutagenesis | 65 | Loss of DNA binding. | ||||
Sequence: N → D | ||||||
Mutagenesis | 74 | Loss of DNA binding. | ||||
Sequence: K → A, L, or M | ||||||
Mutagenesis | 76 | Loss of transcription activation. | ||||
Sequence: C → A | ||||||
Mutagenesis | 82 | Loss of transcription activation. | ||||
Sequence: C → A | ||||||
Mutagenesis | 113 | Loss of transcription activation. | ||||
Sequence: C → A | ||||||
Mutagenesis | 125 | Loss of transcription activation. | ||||
Sequence: C → A | ||||||
Mutagenesis | 152 | Loss of transcription activation. | ||||
Sequence: H → A | ||||||
Mutagenesis | 154 | Loss of transcription activation. | ||||
Sequence: H → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 34 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000126648 | 1-436 | Chorion-specific transcription factor GCMa | |||
Sequence: MELDDFDPEDKEILSWDINDVKLPQNVKTTDWFQEWPDSYVKHIYSSDDRNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICDKARQKQQRKSCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPRPETKLEAEARRAMKKVHMASASNSLRMKGRPAAKALPAEIPSQGSLPLTWSFQEGVQLPGTYSTPLIANAPQQNSLNDCLSFPKSYDLGGSTELEDPTSTLDSMKFYERCKFSSSRIYGSEEQFQPPVPGTYGDYEDLQTWNKNVALGRNPSDDIYYPAYPLPVASWPYDYFPSQNSLEHLPQQVPSEPPAAQPGCHPLWSNPGGEPYEEKVSVDLSSYVPSLTYHPPQQDPFLLTYGSPTQQQHALPGKSNRWDFDEEMACMGLDHFNNEMLLNFCSLR |
Post-translational modification
Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Sequence
- Sequence statusComplete
- Length436
- Mass (Da)49,589
- Last updated1997-02-01 v1
- Checksum99F4E441800582DB
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 211 | in Ref. 2; BAA13650 | ||||
Sequence: G → S | ||||||
Sequence conflict | 230 | in Ref. 2; BAA13650 | ||||
Sequence: N → K | ||||||
Sequence conflict | 241 | in Ref. 2; BAA13650 | ||||
Sequence: S → N | ||||||
Sequence conflict | 413 | in Ref. 2; BAA13650 | ||||
Sequence: D → E |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U59876 EMBL· GenBank· DDBJ | AAC52822.1 EMBL· GenBank· DDBJ | mRNA | ||
D88612 EMBL· GenBank· DDBJ | BAA13650.1 EMBL· GenBank· DDBJ | mRNA | ||
BC066866 EMBL· GenBank· DDBJ | AAH66866.1 EMBL· GenBank· DDBJ | mRNA |