P70310 · NTR2_MOUSE

  • Protein
    Neurotensin receptor type 2
  • Gene
    Ntsr2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled neurotensin receptor activity
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway
Biological Processregulation of membrane potential

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Neurotensin receptor type 2
  • Short names
    NT-R-2; NTR2
  • Alternative names
    • Low-affinity levocabastine-sensitive neurotensin receptor
    • NTRL

Gene names

    • Name
      Ntsr2

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P70310
  • Secondary accessions
    • Q8VIF5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-32Extracellular
Transmembrane33-55Helical; Name=1
Topological domain56-64Cytoplasmic
Transmembrane65-87Helical; Name=2
Topological domain88-109Extracellular
Transmembrane110-131Helical; Name=3
Topological domain132-154Cytoplasmic
Transmembrane155-176Helical; Name=4
Topological domain177-217Extracellular
Transmembrane218-237Helical; Name=5
Topological domain238-297Cytoplasmic
Transmembrane298-318Helical; Name=6
Topological domain319-337Extracellular
Transmembrane338-358Helical; Name=7
Topological domain359-416Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, disulfide bond, lipidation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000699501-416Neurotensin receptor type 2
Disulfide bond108↔194
Lipidation377S-palmitoyl cysteine
Modified residue410Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed maximally in the cerebellum, hippocampus, piriform cortex and neocortex of adult brain.

Developmental stage

Expressed poorly in 7-day-old brain. Expression increases at day 15 to reach a maximal level in 35-day-old brain.

Gene expression databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    416
  • Mass (Da)
    46,376
  • Last updated
    2013-10-16 v2
  • Checksum
    290F8CCB726694B4
METSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFALGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEMERADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFVLPLALTAFLNGITVNHLVALYSQVPSASAQVNSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTDELYDFYHYFYMVTNTLFYVSSAVTPVLYNAVSSSFRKLFLESLSSLCGEQRSVVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1Y7VNS4A0A1Y7VNS4_MOUSENtsr2236
A0A1Y7VN85A0A1Y7VN85_MOUSENtsr2281
A0A1Y7VIR1A0A1Y7VIR1_MOUSENtsr2281

Sequence caution

The sequence AAB17285.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict62in Ref. 1; AAB17285
Sequence conflict153in Ref. 1; AAB17285
Sequence conflict224in Ref. 1; AAB17285

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U51908
EMBL· GenBank· DDBJ
AAB17285.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AB041827
EMBL· GenBank· DDBJ
BAB79257.1
EMBL· GenBank· DDBJ
mRNA
AK158943
EMBL· GenBank· DDBJ
BAE34736.1
EMBL· GenBank· DDBJ
mRNA
AC122228
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC141019
EMBL· GenBank· DDBJ
AAI41020.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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