P70310 · NTR2_MOUSE
- ProteinNeurotensin receptor type 2
- GeneNtsr2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids416 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled neurotensin receptor activity | |
Biological Process | phospholipase C-activating G protein-coupled receptor signaling pathway | |
Biological Process | regulation of membrane potential |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNeurotensin receptor type 2
- Short namesNT-R-2; NTR2
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP70310
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-32 | Extracellular | ||||
Sequence: METSSLWPPRPSPSAGLSLEARLGVDTRLWAK | ||||||
Transmembrane | 33-55 | Helical; Name=1 | ||||
Sequence: VLFTALYSLIFALGTAGNALSVH | ||||||
Topological domain | 56-64 | Cytoplasmic | ||||
Sequence: VVLKARAGR | ||||||
Transmembrane | 65-87 | Helical; Name=2 | ||||
Sequence: PGRLRYHVLSLALSALLLLLISV | ||||||
Topological domain | 88-109 | Extracellular | ||||
Sequence: PMELYNFVWSHYPWVFGDLGCR | ||||||
Transmembrane | 110-131 | Helical; Name=3 | ||||
Sequence: GYYFVRELCAYATVLSVASLSA | ||||||
Topological domain | 132-154 | Cytoplasmic | ||||
Sequence: ERCLAVCQPLRARRLLTPRRTRR | ||||||
Transmembrane | 155-176 | Helical; Name=4 | ||||
Sequence: LLSLVWVASLGLALPMAVIMGQ | ||||||
Topological domain | 177-217 | Extracellular | ||||
Sequence: KHEMERADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFVL | ||||||
Transmembrane | 218-237 | Helical; Name=5 | ||||
Sequence: PLALTAFLNGITVNHLVALY | ||||||
Topological domain | 238-297 | Cytoplasmic | ||||
Sequence: SQVPSASAQVNSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQ | ||||||
Transmembrane | 298-318 | Helical; Name=6 | ||||
Sequence: VLRAIVAVYVICWLPYHARRL | ||||||
Topological domain | 319-337 | Extracellular | ||||
Sequence: MYCYIPDDGWTDELYDFYH | ||||||
Transmembrane | 338-358 | Helical; Name=7 | ||||
Sequence: YFYMVTNTLFYVSSAVTPVLY | ||||||
Topological domain | 359-416 | Cytoplasmic | ||||
Sequence: NAVSSSFRKLFLESLSSLCGEQRSVVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, disulfide bond, lipidation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069950 | 1-416 | Neurotensin receptor type 2 | |||
Sequence: METSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFALGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEMERADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFVLPLALTAFLNGITVNHLVALYSQVPSASAQVNSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTDELYDFYHYFYMVTNTLFYVSSAVTPVLYNAVSSSFRKLFLESLSSLCGEQRSVVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV | ||||||
Disulfide bond | 108↔194 | |||||
Sequence: CRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEMERADGEPEPASRVC | ||||||
Lipidation | 377 | S-palmitoyl cysteine | ||||
Sequence: C | ||||||
Modified residue | 410 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed maximally in the cerebellum, hippocampus, piriform cortex and neocortex of adult brain.
Developmental stage
Expressed poorly in 7-day-old brain. Expression increases at day 15 to reach a maximal level in 35-day-old brain.
Gene expression databases
Structure
Family & Domains
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)46,376
- Last updated2013-10-16 v2
- Checksum290F8CCB726694B4
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1Y7VNS4 | A0A1Y7VNS4_MOUSE | Ntsr2 | 236 | ||
A0A1Y7VN85 | A0A1Y7VN85_MOUSE | Ntsr2 | 281 | ||
A0A1Y7VIR1 | A0A1Y7VIR1_MOUSE | Ntsr2 | 281 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 62 | in Ref. 1; AAB17285 | ||||
Sequence: A → T | ||||||
Sequence conflict | 153 | in Ref. 1; AAB17285 | ||||
Sequence: R → C | ||||||
Sequence conflict | 224 | in Ref. 1; AAB17285 | ||||
Sequence: F → I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U51908 EMBL· GenBank· DDBJ | AAB17285.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AB041827 EMBL· GenBank· DDBJ | BAB79257.1 EMBL· GenBank· DDBJ | mRNA | ||
AK158943 EMBL· GenBank· DDBJ | BAE34736.1 EMBL· GenBank· DDBJ | mRNA | ||
AC122228 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC141019 EMBL· GenBank· DDBJ | AAI41020.1 EMBL· GenBank· DDBJ | mRNA |