P70298 · CUX2_MOUSE
- ProteinHomeobox protein cut-like 2
- GeneCux2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1426 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Transcription factor involved in the control of neuronal proliferation and differentiation in the brain (PubMed:18033766, PubMed:20510857).
Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III (PubMed:20510857).
Binds to DNA in a sequence-specific manner
Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III (PubMed:20510857).
Binds to DNA in a sequence-specific manner
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 482-569 | CUT 1 | ||||
Sequence: DGAGPEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVR | ||||||
DNA binding | 828-915 | CUT 2 | ||||
Sequence: QYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQGQGQAPTQQ | ||||||
DNA binding | 983-1070 | CUT 3 | ||||
Sequence: QEMVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLSDPHNVEKLRDMKKL | ||||||
DNA binding | 1113-1172 | Homeobox | ||||
Sequence: AKKPRVVLAPAEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREM |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of dendrite morphogenesis | |
Biological Process | positive regulation of dendritic spine morphogenesis | |
Biological Process | positive regulation of excitatory postsynaptic potential | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of synapse assembly | |
Biological Process | regulation of transcription by RNA polymerase II | |
Biological Process | short-term memory |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHomeobox protein cut-like 2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP70298
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Knockout mice show moderately but consistently bigger brains than wild-type animals. Cell density and thickness of upper cortical layers (II-IV) are increased, while there are no differences in neuronal density in layers V and VI (PubMed:18033766).
Neurons in layer II-III show simpler morphologies, with a significant decrease in the dendritic length and the number of branches, as well as a severe reduction of dendritic spines density associated with synaptic defects. The working memory is impaired (PubMed:20510857).
Neurons in layer II-III show simpler morphologies, with a significant decrease in the dendritic length and the number of branches, as well as a severe reduction of dendritic spines density associated with synaptic defects. The working memory is impaired (PubMed:20510857).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 67 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000202397 | 1-1426 | Homeobox protein cut-like 2 | |||
Sequence: MVAPVLKSFQAEVVALSKRSREAEAAFLSVYKQLIEAPDPVPSFEVARTLDDRLQRPSFDPSGQRLQDVHIAWKRCPEPPSAREQNEGTCPTGHTPANGNHLPGPEDTLVTDTLLQKNEAERQKGLQEVHITLAARLGEAEEKIKVLHSALKATQTELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGEKVSFALCSGPRLEAALASKDREILRLLKDAQQLRHSLQELEEVSANQIADLERQLAAKSEAIEKLQEKLEAQADYEEIKTELSILRAMKLASSTCSLPQTLAKPDDPLLVAKDVFFPTQKFLLEKPALLASPEEDPSEDDSIKGSLGTEPPYPPQLPPPPGPEDPLSPSPAQPLLGPSLGPDGPRTFSLSPFPSLAPGERLAGDSLLSKHMMGPAAFKGETGNLLAFPPTFYGGAKPPSAPAASVPCPEPTGAPEAVDGAGPEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGSITPRIRTPETGSDDAIKSILEQAKKEIESQKGGESKNSPASVSIPNGTASSSTSEDAIKNILEQARREMQAQQQALLEMESGPRGRSVPPSPPERPSPATASQNGALTCVKQEDGGGGSGSSSTVQAPLAVLSPAAFVQRIIRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSYSGQPNGRAWPRGDEATIAPEDEAAMGEDEAPRVGELKAEAGAPEVGGGRLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQGQGQAPTQQPSASQASPTEPTSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQPEGRASSSLGGKPFSSSQAAGGIQEMVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLSDPHNVEKLRDMKKLEKKAYLKRRYGLIGTGSDSESPAAHSECPSPCLQPQELSLMQAKKPRVVLAPAEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGTQDDPDFDPSGGPNVLTPGHTHREPTPQSPDSETEDQKPPMKSLELQEPEGPLQRAAPDRALVKIKQEEGLEVDGDSQPQDVGDPDRGQDGPKEEHTHPLGNSDLSELAPGPFLSGTPNPDCPSLHNPQEKGTGEQVHSEPLSFKSTSESSCCSLEGPPNSPSVISSPDLTTCVSPAPSSSAPISPSLPGAPPAKVPSTSPTGDTAAALHPSTKVNPNLQRRHEKMANLNSIIYRLERAANREEVLEWEF | ||||||
Modified residue | 81 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 77-104 | Disordered | ||||
Sequence: PEPPSAREQNEGTCPTGHTPANGNHLPG | ||||||
Coiled coil | 131-311 | |||||
Sequence: ITLAARLGEAEEKIKVLHSALKATQTELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGEKVSFALCSGPRLEAALASKDREILRLLKDAQQLRHSLQELEEVSANQIADLERQLAAKSEAIEKLQEKLEAQADYEEIKTELSILRA | ||||||
Region | 351-419 | Disordered | ||||
Sequence: ALLASPEEDPSEDDSIKGSLGTEPPYPPQLPPPPGPEDPLSPSPAQPLLGPSLGPDGPRTFSLSPFPSL | ||||||
Compositional bias | 374-401 | Pro residues | ||||
Sequence: PPYPPQLPPPPGPEDPLSPSPAQPLLGP | ||||||
Region | 460-488 | Disordered | ||||
Sequence: KPPSAPAASVPCPEPTGAPEAVDGAGPEE | ||||||
Coiled coil | 587-655 | |||||
Sequence: DAIKSILEQAKKEIESQKGGESKNSPASVSIPNGTASSSTSEDAIKNILEQARREMQAQQQALLEMESG | ||||||
Region | 599-628 | Disordered | ||||
Sequence: EIESQKGGESKNSPASVSIPNGTASSSTSE | ||||||
Compositional bias | 606-628 | Polar residues | ||||
Sequence: GESKNSPASVSIPNGTASSSTSE | ||||||
Region | 653-676 | Disordered | ||||
Sequence: ESGPRGRSVPPSPPERPSPATASQ | ||||||
Region | 743-769 | Disordered | ||||
Sequence: YASVSPSLSSSSSYSGQPNGRAWPRGD | ||||||
Compositional bias | 744-761 | Polar residues | ||||
Sequence: ASVSPSLSSSSSYSGQPN | ||||||
Compositional bias | 904-925 | Polar residues | ||||
Sequence: LGQGQGQAPTQQPSASQASPTE | ||||||
Region | 904-977 | Disordered | ||||
Sequence: LGQGQGQAPTQQPSASQASPTEPTSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQPEGRASSSLGGKPFSSSQ | ||||||
Compositional bias | 926-940 | Pro residues | ||||
Sequence: PTSSPSPPPSPTEPE | ||||||
Compositional bias | 941-977 | Polar residues | ||||
Sequence: KTSQEPLGLSLESSKENQQPEGRASSSLGGKPFSSSQ | ||||||
Region | 1177-1392 | Disordered | ||||
Sequence: TQDDPDFDPSGGPNVLTPGHTHREPTPQSPDSETEDQKPPMKSLELQEPEGPLQRAAPDRALVKIKQEEGLEVDGDSQPQDVGDPDRGQDGPKEEHTHPLGNSDLSELAPGPFLSGTPNPDCPSLHNPQEKGTGEQVHSEPLSFKSTSESSCCSLEGPPNSPSVISSPDLTTCVSPAPSSSAPISPSLPGAPPAKVPSTSPTGDTAAALHPSTKVN | ||||||
Compositional bias | 1202-1219 | Basic and acidic residues | ||||
Sequence: TPQSPDSETEDQKPPMKS | ||||||
Compositional bias | 1256-1277 | Basic and acidic residues | ||||
Sequence: QDVGDPDRGQDGPKEEHTHPLG | ||||||
Compositional bias | 1296-1357 | Polar residues | ||||
Sequence: PDCPSLHNPQEKGTGEQVHSEPLSFKSTSESSCCSLEGPPNSPSVISSPDLTTCVSPAPSSS | ||||||
Compositional bias | 1358-1372 | Pro residues | ||||
Sequence: APISPSLPGAPPAKV | ||||||
Compositional bias | 1374-1392 | Polar residues | ||||
Sequence: STSPTGDTAAALHPSTKVN |
Sequence similarities
Belongs to the CUT homeobox family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,426
- Mass (Da)154,664
- Last updated2011-07-27 v2
- Checksum485B87D1C88D2577
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 199 | in Ref. 1; AAC52762 | ||||
Sequence: S → G | ||||||
Sequence conflict | 209 | in Ref. 1; AAC52762 | ||||
Sequence: S → N | ||||||
Sequence conflict | 324 | in Ref. 1; AAC52762 | ||||
Sequence: T → M | ||||||
Compositional bias | 374-401 | Pro residues | ||||
Sequence: PPYPPQLPPPPGPEDPLSPSPAQPLLGP | ||||||
Sequence conflict | 410 | in Ref. 1; AAC52762 | ||||
Sequence: T → N | ||||||
Compositional bias | 606-628 | Polar residues | ||||
Sequence: GESKNSPASVSIPNGTASSSTSE | ||||||
Compositional bias | 744-761 | Polar residues | ||||
Sequence: ASVSPSLSSSSSYSGQPN | ||||||
Compositional bias | 904-925 | Polar residues | ||||
Sequence: LGQGQGQAPTQQPSASQASPTE | ||||||
Compositional bias | 926-940 | Pro residues | ||||
Sequence: PTSSPSPPPSPTEPE | ||||||
Compositional bias | 941-977 | Polar residues | ||||
Sequence: KTSQEPLGLSLESSKENQQPEGRASSSLGGKPFSSSQ | ||||||
Compositional bias | 1202-1219 | Basic and acidic residues | ||||
Sequence: TPQSPDSETEDQKPPMKS | ||||||
Compositional bias | 1256-1277 | Basic and acidic residues | ||||
Sequence: QDVGDPDRGQDGPKEEHTHPLG | ||||||
Compositional bias | 1296-1357 | Polar residues | ||||
Sequence: PDCPSLHNPQEKGTGEQVHSEPLSFKSTSESSCCSLEGPPNSPSVISSPDLTTCVSPAPSSS | ||||||
Compositional bias | 1358-1372 | Pro residues | ||||
Sequence: APISPSLPGAPPAKV | ||||||
Compositional bias | 1374-1392 | Polar residues | ||||
Sequence: STSPTGDTAAALHPSTKVN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U45665 EMBL· GenBank· DDBJ | AAC52762.1 EMBL· GenBank· DDBJ | mRNA | ||
BC065113 EMBL· GenBank· DDBJ | AAH65113.1 EMBL· GenBank· DDBJ | mRNA |