P70298 · CUX2_MOUSE

  • Protein
    Homeobox protein cut-like 2
  • Gene
    Cux2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Transcription factor involved in the control of neuronal proliferation and differentiation in the brain (PubMed:18033766, PubMed:20510857).
Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III (PubMed:20510857).
Binds to DNA in a sequence-specific manner

Features

Showing features for dna binding.

114262004006008001,0001,2001,400
TypeIDPosition(s)Description
DNA binding482-569CUT 1
DNA binding828-915CUT 2
DNA binding983-1070CUT 3
DNA binding1113-1172Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of dendrite morphogenesis
Biological Processpositive regulation of dendritic spine morphogenesis
Biological Processpositive regulation of excitatory postsynaptic potential
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of synapse assembly
Biological Processregulation of transcription by RNA polymerase II
Biological Processshort-term memory

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox protein cut-like 2
  • Alternative names
    • Homeobox protein Cux-2

Gene names

    • Name
      Cux2
    • Synonyms
      Cutl2

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P70298
  • Secondary accessions
    • Q6P1E6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Knockout mice show moderately but consistently bigger brains than wild-type animals. Cell density and thickness of upper cortical layers (II-IV) are increased, while there are no differences in neuronal density in layers V and VI (PubMed:18033766).
Neurons in layer II-III show simpler morphologies, with a significant decrease in the dendritic length and the number of branches, as well as a severe reduction of dendritic spines density associated with synaptic defects. The working memory is impaired (PubMed:20510857).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 67 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002023971-1426Homeobox protein cut-like 2
Modified residue81Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Region77-104Disordered
Coiled coil131-311
Region351-419Disordered
Compositional bias374-401Pro residues
Region460-488Disordered
Coiled coil587-655
Region599-628Disordered
Compositional bias606-628Polar residues
Region653-676Disordered
Region743-769Disordered
Compositional bias744-761Polar residues
Compositional bias904-925Polar residues
Region904-977Disordered
Compositional bias926-940Pro residues
Compositional bias941-977Polar residues
Region1177-1392Disordered
Compositional bias1202-1219Basic and acidic residues
Compositional bias1256-1277Basic and acidic residues
Compositional bias1296-1357Polar residues
Compositional bias1358-1372Pro residues
Compositional bias1374-1392Polar residues

Sequence similarities

Belongs to the CUT homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,426
  • Mass (Da)
    154,664
  • Last updated
    2011-07-27 v2
  • Checksum
    485B87D1C88D2577
MVAPVLKSFQAEVVALSKRSREAEAAFLSVYKQLIEAPDPVPSFEVARTLDDRLQRPSFDPSGQRLQDVHIAWKRCPEPPSAREQNEGTCPTGHTPANGNHLPGPEDTLVTDTLLQKNEAERQKGLQEVHITLAARLGEAEEKIKVLHSALKATQTELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGEKVSFALCSGPRLEAALASKDREILRLLKDAQQLRHSLQELEEVSANQIADLERQLAAKSEAIEKLQEKLEAQADYEEIKTELSILRAMKLASSTCSLPQTLAKPDDPLLVAKDVFFPTQKFLLEKPALLASPEEDPSEDDSIKGSLGTEPPYPPQLPPPPGPEDPLSPSPAQPLLGPSLGPDGPRTFSLSPFPSLAPGERLAGDSLLSKHMMGPAAFKGETGNLLAFPPTFYGGAKPPSAPAASVPCPEPTGAPEAVDGAGPEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGSITPRIRTPETGSDDAIKSILEQAKKEIESQKGGESKNSPASVSIPNGTASSSTSEDAIKNILEQARREMQAQQQALLEMESGPRGRSVPPSPPERPSPATASQNGALTCVKQEDGGGGSGSSSTVQAPLAVLSPAAFVQRIIRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSYSGQPNGRAWPRGDEATIAPEDEAAMGEDEAPRVGELKAEAGAPEVGGGRLPYYPAYVPRTLKPTVPPLTPEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQLGQGQGQAPTQQPSASQASPTEPTSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQPEGRASSSLGGKPFSSSQAAGGIQEMVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLSDPHNVEKLRDMKKLEKKAYLKRRYGLIGTGSDSESPAAHSECPSPCLQPQELSLMQAKKPRVVLAPAEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGTQDDPDFDPSGGPNVLTPGHTHREPTPQSPDSETEDQKPPMKSLELQEPEGPLQRAAPDRALVKIKQEEGLEVDGDSQPQDVGDPDRGQDGPKEEHTHPLGNSDLSELAPGPFLSGTPNPDCPSLHNPQEKGTGEQVHSEPLSFKSTSESSCCSLEGPPNSPSVISSPDLTTCVSPAPSSSAPISPSLPGAPPAKVPSTSPTGDTAAALHPSTKVNPNLQRRHEKMANLNSIIYRLERAANREEVLEWEF

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3YUK2D3YUK2_MOUSECux261
F6YIR2F6YIR2_MOUSECux2147

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict199in Ref. 1; AAC52762
Sequence conflict209in Ref. 1; AAC52762
Sequence conflict324in Ref. 1; AAC52762
Compositional bias374-401Pro residues
Sequence conflict410in Ref. 1; AAC52762
Compositional bias606-628Polar residues
Compositional bias744-761Polar residues
Compositional bias904-925Polar residues
Compositional bias926-940Pro residues
Compositional bias941-977Polar residues
Compositional bias1202-1219Basic and acidic residues
Compositional bias1256-1277Basic and acidic residues
Compositional bias1296-1357Polar residues
Compositional bias1358-1372Pro residues
Compositional bias1374-1392Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U45665
EMBL· GenBank· DDBJ
AAC52762.1
EMBL· GenBank· DDBJ
mRNA
BC065113
EMBL· GenBank· DDBJ
AAH65113.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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