P70274 · SEPP1_MOUSE

  • Protein
    Selenoprotein P
  • Gene
    Selenop
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium (By similarity).
May supply selenium to tissues such as brain and testis

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functionselenium binding
Biological Processbrain development
Biological Processlocomotory behavior
Biological Processpost-embryonic development
Biological Processregulation of growth
Biological Processresponse to selenium ion
Biological Processselenium compound metabolic process
Biological Processsexual reproduction

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 9.B.88.1.1the putative selenoprotein p hydrogen selenide uptake protein (selp) family

Names & Taxonomy

Protein names

  • Recommended name
    Selenoprotein P
  • Short names
    SeP
  • Alternative names
    • Plasma selenoprotein P

Gene names

    • Name
      Selenop
    • Synonyms
      Selp
      , Sepp1

Organism names

  • Taxonomic identifier
  • Strains
    • 129
    • Swiss Webster / NIH
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P70274
  • Secondary accessions
    • Q3TJ31
    • Q3TXG8
    • Q6PKE7
    • Q80T08
    • Q80UF3
    • Q9Z2T7

Proteomes

Organism-specific databases

Subcellular Location

Secreted
Note: Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium.

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000002231420-380Selenoprotein P
Glycosylation83N-linked (GlcNAc...) asparagine
Glycosylation176N-linked (GlcNAc...) asparagine
Glycosylation195N-linked (GlcNAc...) asparagine
Modified residue264Phosphoserine
Glycosylation365N-linked (GlcNAc...) asparagine
Glycosylation370N-linked (GlcNAc...) asparagine

Post-translational modification

Phosphorylation sites are present in the extracellular medium.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In the kidney, expressed in the cortex with no expression observed in the medulla (at protein level) (PubMed:18174160).
Expressed by the liver and secreted in plasma (PubMed:9687017).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region196-263Disordered
Compositional bias220-235Polar residues
Compositional bias346-374Polar residues
Region346-380Disordered

Domain

The C-terminus is not required for endocytic uptake in the proximal tubule epithelium.

Sequence similarities

Belongs to the selenoprotein P family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    380
  • Mass (Da)
    42,706
  • Last updated
    2008-02-26 v3
  • Checksum
    0972BF4993CC208D
MWRSLGLALALCLLPYGGAESQGQSSACYKAPEWYIGDQNPMLNSEGKVTVVALLQASUYLCLLQASRLEDLRIKLESQGYFNISYIVVNHQGSPSQLKHSHLKKQVSEHIAVYRQEEDGIDVWTLLNGNKDDFLIYDRCGRLVYHLGLPYSFLTFPYVEEAIKIAYCEERCGNCNLTSLEDEDFCKTVTSATANKTAEPSEAHSHHKHHNKHGQEHLGSSKPSENQQPGPSETTLPPSGLHHHHRHRGQHRQGHLESUDTTASEGLHLSLAQRKLURRGCINQLLCKLSKESEAAPSSCCCHCRHLIFEKSGSAIAUQCAENLPSLCSUQGLFAEEKVTESCQCRSPPAAUQNQPMNPMEANPNUSUDNQTRKUKUHSN

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E0CZ76E0CZ76_MOUSESelenop124
E0CX80E0CX80_MOUSESelenop177
E0CY03E0CY03_MOUSESelenop110

Features

Showing features for non-standard residue, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Non-standard residue59Selenocysteine
Sequence conflict184in Ref. 3; BAC55264
Sequence conflict188in Ref. 2; AAD01684 and 4; AAH01991
Sequence conflict192in Ref. 2; AAD01684
Sequence conflict203in Ref. 2; AAD01684
Compositional bias220-235Polar residues
Non-standard residue259Selenocysteine
Sequence conflict264in Ref. 3; BAE34948
Non-standard residue277Selenocysteine
Sequence conflict308in Ref. 3; BAC55264
Non-standard residue318Selenocysteine
Sequence conflict321in Ref. 4; AAH01991
Non-standard residue330Selenocysteine
Compositional bias346-374Polar residues
Non-standard residue352Selenocysteine
Non-standard residue366Selenocysteine
Non-standard residue368Selenocysteine
Non-standard residue375Selenocysteine
Non-standard residue377Selenocysteine

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X99807
EMBL· GenBank· DDBJ
CAA68140.2
EMBL· GenBank· DDBJ
mRNA
AF021345
EMBL· GenBank· DDBJ
AAD01684.1
EMBL· GenBank· DDBJ
Genomic DNA
AK002450
EMBL· GenBank· DDBJ
BAC55246.3
EMBL· GenBank· DDBJ
mRNA
AK077265
EMBL· GenBank· DDBJ
BAC55264.3
EMBL· GenBank· DDBJ
mRNA
AK146774
EMBL· GenBank· DDBJ
BAE27423.1
EMBL· GenBank· DDBJ
mRNA
AK148623
EMBL· GenBank· DDBJ
BAE28626.1
EMBL· GenBank· DDBJ
mRNA
AK159269
EMBL· GenBank· DDBJ
BAE34948.1
EMBL· GenBank· DDBJ
mRNA
AK159524
EMBL· GenBank· DDBJ
BAE35153.1
EMBL· GenBank· DDBJ
mRNA
AK159894
EMBL· GenBank· DDBJ
BAE35460.1
EMBL· GenBank· DDBJ
mRNA
AK159911
EMBL· GenBank· DDBJ
BAE35474.1
EMBL· GenBank· DDBJ
mRNA
AK159935
EMBL· GenBank· DDBJ
BAE35495.1
EMBL· GenBank· DDBJ
mRNA
AK167611
EMBL· GenBank· DDBJ
BAE39664.1
EMBL· GenBank· DDBJ
mRNA
AK168463
EMBL· GenBank· DDBJ
BAE40359.1
EMBL· GenBank· DDBJ
mRNA
AK168583
EMBL· GenBank· DDBJ
BAE40452.1
EMBL· GenBank· DDBJ
mRNA
AK168631
EMBL· GenBank· DDBJ
BAE40491.1
EMBL· GenBank· DDBJ
mRNA
AK168747
EMBL· GenBank· DDBJ
BAE40587.1
EMBL· GenBank· DDBJ
mRNA
AK168926
EMBL· GenBank· DDBJ
BAE40739.1
EMBL· GenBank· DDBJ
mRNA
AK169011
EMBL· GenBank· DDBJ
BAE40808.1
EMBL· GenBank· DDBJ
mRNA
AK169158
EMBL· GenBank· DDBJ
BAE40937.1
EMBL· GenBank· DDBJ
mRNA
AK169362
EMBL· GenBank· DDBJ
BAE41111.1
EMBL· GenBank· DDBJ
mRNA
BC001991
EMBL· GenBank· DDBJ
AAH01991.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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