P70085 · CP17A_ORYLA
- ProteinSteroid 17-alpha-hydroxylase/17,20 lyase
- Genecyp17a1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids517 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.
Catalytic activity
- a C21-steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 17alpha-hydroxy-C21-steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H+
Cofactor
Pathway
Lipid metabolism; steroid biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 451 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | lyase activity | |
Molecular Function | steroid 17-alpha-monooxygenase activity | |
Biological Process | hormone biosynthetic process | |
Biological Process | progesterone metabolic process | |
Biological Process | steroid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSteroid 17-alpha-hydroxylase/17,20 lyase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionP70085
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000051946 | 1-517 | Steroid 17-alpha-hydroxylase/17,20 lyase | ||
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P70085-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameC17L
- Length517
- Mass (Da)57,524
- Last updated1997-02-01 v1
- MD5 Checksum16D14CCC3C1AF758F51D7F594E93767B
P70085-2
- NameC17S
- Differences from canonical
- 230-258: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H2MY89 | H2MY89_ORYLA | cyp17 | 595 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_000615 | 230-258 | in isoform C17S | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D87121 EMBL· GenBank· DDBJ | BAA13252.1 EMBL· GenBank· DDBJ | mRNA | ||
D87122 EMBL· GenBank· DDBJ | BAA13253.1 EMBL· GenBank· DDBJ | mRNA |