P70085 · CP17A_ORYLA

Function

function

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Lipid metabolism; steroid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site451Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionlyase activity
Molecular Functionsteroid 17-alpha-monooxygenase activity
Biological Processhormone biosynthetic process
Biological Processprogesterone metabolic process
Biological Processsteroid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Steroid 17-alpha-hydroxylase/17,20 lyase
  • EC number
  • Alternative names
    • 17-alpha-hydroxyprogesterone aldolase
    • CYPXVII
    • Cytochrome P450 17A1
    • Cytochrome P450-C17 (Cytochrome P450c17)

Gene names

    • Name
      cyp17a1
    • Synonyms
      cyp17

Organism names

  • Taxonomic identifier
  • Strain
    • Orange-red
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    P70085
  • Secondary accessions
    • P70086

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000519461-517Steroid 17-alpha-hydroxylase/17,20 lyase

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P70085-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    C17L
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    517
  • Mass (Da)
    57,524
  • Last updated
    1997-02-01 v1
  • MD5 Checksum
    16D14CCC3C1AF758F51D7F594E93767B
MAWFLCLSVLVVLVLALAALLWRVRTRDRPQEAPSLPYLPVLGSLLSLRSPHPPHVLFKELQQKYGQTYSLKMGSHQVIIVNHHAHAREVLLKRGRTFAGRPRTVTTDVLTRDGKDIAFGDYSATWRFHRKIVHGALCMFGEGSASLQRIICTEAQSLCSTLSEAAATGLALDLSPELTRAVTNVICSLCFNSSYSRGDPEFEAMLRYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRLLKQCVAVRDQLLQKKFEEHKSDYSDHVQRDLLDALLRAKRSAENNNTAAEFSAEAVGLSDDHLLMTVGDIFGAGVETTTTVLKWAITYLIHYPEVQKQIQEELDRKVGVDRPPQLSDRGSLPFLEATIREVLRIRPVAPLLIPHVALSDTSLGDFTVRKGTRVVINLWSLHHDEKEWTNPDLFNPGRFLSADGSSLTLPSSSYLPFGAGLRVCLGEALAKMELFLFLSWILQRFTLSVPPSQSLPSLEGKFGVVLQPVKYAVKATPRPGCHSGLFPANP

P70085-2

  • Name
    C17S
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H2MY89H2MY89_ORYLAcyp17595

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_000615230-258in isoform C17S

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D87121
EMBL· GenBank· DDBJ
BAA13252.1
EMBL· GenBank· DDBJ
mRNA
D87122
EMBL· GenBank· DDBJ
BAA13253.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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