P70030 · P3F2B_XENLA
- ProteinPOU domain, class 3, transcription factor 2-B
- Genepou3f2-b
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids385 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Transcription factor that may be implicated in patterning of the central nervous system during early development.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 296-355 | Homeobox | ||||
Sequence: KRKKRTSIEVSVKGALESHFLKCPKPAAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMT |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Biological Process | brain development |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended namePOU domain, class 3, transcription factor 2-B
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionP70030
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000100726 | 1-385 | POU domain, class 3, transcription factor 2-B | |||
Sequence: MATTASNHYNLLGSGSSIVHADPGGMQQAQSYRDAQTLVQSDYTLQSNGHPLSHAHQWITALSHGDGAPWATSPLGQQDIKPTVQSSRDELHGSGTLQHQSRAPHLVHPAHGNHHGPGAWRSTGSTHLSSMASSNGQGLLYSQPSFTVNGMINPGSGQGMHHHGLRDSHDDHHGDHGHQQPSQTQQQQQQHSQLQGGHHDHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPAAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTIPGAEDVYGASRDTPPHLGVQTSVQ |
Expression
Tissue specificity
Expressed in the developing brain and spinal cord. Also found in a restricted region of the auditory vesicle during development. In the adult, expression is restricted to the brain.
Developmental stage
First expressed at the neurula stage.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 106-136 | Disordered | ||||
Sequence: LVHPAHGNHHGPGAWRSTGSTHLSSMASSNG | ||||||
Compositional bias | 119-136 | Polar residues | ||||
Sequence: AWRSTGSTHLSSMASSNG | ||||||
Region | 149-209 | Disordered | ||||
Sequence: NGMINPGSGQGMHHHGLRDSHDDHHGDHGHQQPSQTQQQQQQHSQLQGGHHDHSDEDTPTS | ||||||
Compositional bias | 162-178 | Basic and acidic residues | ||||
Sequence: HHGLRDSHDDHHGDHGH | ||||||
Compositional bias | 179-195 | Polar residues | ||||
Sequence: QQPSQTQQQQQQHSQLQ | ||||||
Domain | 204-278 | POU-specific | ||||
Sequence: EDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEAD | ||||||
Region | 351-385 | Disordered | ||||
Sequence: EKRMTPPGGTIPGAEDVYGASRDTPPHLGVQTSVQ |
Sequence similarities
Belongs to the POU transcription factor family. Class-3 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length385
- Mass (Da)41,985
- Last updated1997-02-01 v1
- Checksum59001F5CCC0B2F3D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 119-136 | Polar residues | ||||
Sequence: AWRSTGSTHLSSMASSNG | ||||||
Compositional bias | 162-178 | Basic and acidic residues | ||||
Sequence: HHGLRDSHDDHHGDHGH | ||||||
Compositional bias | 179-195 | Polar residues | ||||
Sequence: QQPSQTQQQQQQHSQLQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X96423 EMBL· GenBank· DDBJ | CAA65283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC072060 EMBL· GenBank· DDBJ | AAH72060.1 EMBL· GenBank· DDBJ | mRNA | ||
BC160684 EMBL· GenBank· DDBJ | AAI60684.1 EMBL· GenBank· DDBJ | mRNA |