P69735 · RB3GP_RAT

  • Protein
    Rab3 GTPase-activating protein catalytic subunit
  • Gene
    Rab3gap1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3gap1 and Rab3gap2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (By similarity).
As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity).
Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity).
The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (By similarity).
Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity).
Required for normal eye and brain development (By similarity).
May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentendoplasmic reticulum tubular network
Cellular Componentexcitatory synapse
Cellular ComponentGolgi apparatus
Cellular Componentlipid droplet
Cellular Componentpostsynapse
Cellular Componentprotein-containing complex
Molecular FunctionGTPase activator activity
Molecular Functionsmall GTPase binding
Biological Processbrain development
Biological Processcamera-type eye development
Biological Processestablishment of protein localization to endoplasmic reticulum membrane
Biological Processexcitatory postsynaptic potential
Biological Processface morphogenesis
Biological Processhypothalamus development
Biological Processlipid droplet organization
Biological Processpositive regulation of autophagosome assembly
Biological Processpositive regulation of endoplasmic reticulum tubular network organization
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
Biological Processpositive regulation of protein lipidation
Biological Processregulation of calcium ion-dependent exocytosis of neurotransmitter
Biological Processregulation of Rab protein signal transduction
Biological Processregulation of short-term neuronal synaptic plasticity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rab3 GTPase-activating protein catalytic subunit
  • Alternative names
    • RAB3 GTPase-activating protein 130 kDa subunit
    • Rab3-GAP p130 (Rab3-GAP)

Gene names

    • Name
      Rab3gap1
    • Synonyms
      Rab3gap

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P69735

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001916572-775Rab3 GTPase-activating protein catalytic subunit
Modified residue173Phosphoserine
Modified residue330Phosphoserine
Modified residue373Phosphoserine
Modified residue375Phosphoserine
Modified residue384Phosphoserine
Modified residue458Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

The Rab3 GTPase-activating complex is a heterodimer composed of Rab3gap1 and Rab3gap2 (PubMed:9733780).
The Rab3 GTPase-activating complex interacts with DMXL2 (PubMed:11809763).
Interacts with LMAN1 (By similarity).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region324-351Disordered
Region386-414Disordered

Sequence similarities

Belongs to the Rab3-GAP catalytic subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragments
  • Length
    775
  • Mass (Da)
    86,587
  • Last updated
    2007-01-23 v2
  • Checksum
    DF836260D18EC380
MAADSEPESEVGCPLTPLPPVSIAIRFTYVLQDWQQYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDPVQAPHWSVRVRKADNPQCLLGDFVTEFLKICRRKESTDEILGRSTFEEEGRVADITHALSKLTEPAPVPIHKLSVSNMVHTAKKKIRKHRGEESPLNNDVLNTILLFLFPDAASEKPLDGTTSVDNSNPAAEAGDYTLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSPSDSMTKAYPADAGKAGGQLGLDHLRDTEKEKGEAGKSWDSWSDSEEEFFECLSDAEDLRGNGQESTKKGGPKDMAPLKPEGRLHQHGKLTLLRNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCCLEDFVRWYSPRDYIEEEVTDEKGNVVLKGELSARMKIPSNMWVEAWETAKPVPARRQRRLFDDTREAEKVLHYLAMQKPADLARHLLPCVIHAAVLKVKEEESLENIPSVKKIIKQIIAHSSKVLRFPSPEDKKLEEIILQITTVEAIIARARSLKAKFGTEKCEHEEEKEDLERFVSCLLEQPEVAVTGAGRGHAGRIIHKLFVNAQRAAAVALPEEELKRSGCPEERRQTLVSDFPPPAGRELILRATVPRPAPYSKALPQRMYSVLTKEDFRLAGAFSSDTSFF

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1LP59F1LP59_RATRab3gap1988
A0A0G2JXA1A0A0G2JXA1_RATRab3gap1969
A0A8I6A7Y5A0A8I6A7Y5_RATRab3gap11007

Features

Showing features for non-adjacent residues.

TypeIDPosition(s)Description
Non-adjacent residues11-12

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR03085327
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR03086784
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

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