P69514 · RDRP_CGMVS

Function

function

The replicase large subunit is an RNA-dependent RNA polymerase active in viral RNA replication.
The replicase small subunit is a methyltransferase active in RNA capping and an RNA helicase. It also acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May mediate silencing suppression through either inhibition of HEN1-mediated siRNA or siRNA demethylation (By similarity).

Miscellaneous

Readthrough of the terminator codon UAG occurs between codons for Lys-1144 and Gln-1146.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site863-870ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionmRNA methyltransferase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological ProcessmRNA modification
Biological ProcessRNA processing
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processviral RNA genome replication
Biological Processvirus-mediated perturbation of host defense response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    P69514
  • Secondary accessions
    • P19523
    • P89877
    • P90356
    • Q83208

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000411731-1144Replicase small subunit
ChainPRO_00000411721-1648Replicase large subunit

Interaction

Subunit

Heterodimer of a large and a small subunit.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-20Disordered
Domain72-287Alphavirus-like MT
Domain831-991+RNA virus helicase ATP-binding
Domain992-1144+RNA virus helicase C-terminal
Domain1413-1526RdRp catalytic

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,648
  • Mass (Da)
    186,551
  • Last updated
    2005-03-15 v1
  • Checksum
    1D1AFFEEE7B65595
MANINEQINNQRDAAASGRNNLVSQLASKRVYDEAVRSLDHQDRRPKMNFSRVVSTEHTRLVTDAYPEFSISFTATKNSVHSLAGGLRLLELEYMMMQVPYGSPCYDIGGNYTQHLFKGRSYVHCCNPCLDLKDVARNVMYNDMITQHVQRHKGSGGCRPLPTFQIDAFRRYDSSPCAVTCSDVFQECSYDFGSGRDNHAVSLHSIYDIPYSSIGPALHRKNVRVCYAAFHFSEALLLGSPVGNLNSIGAQFRVDGDDVHFLFSEESTLHYTHSLENIKLIVMRTYFPADDRFVYIKEFMVKRVDTFFFRLVRADTHMLHKSVGHYSKSKSEYFALNTPPIFQDKATFSVWFPEAKRKVLIPKFELSRFLSGNVKISRMLVDADFVHTIINHISTYDNKALVWKNVQSFVESIRSRVIVNGVSVKSEWNVPVDQLTDISFSIFLLVKVRKVQIELMSDKVVIEARGLLRRFADSLKSAVEGLGDCVYDALVQTGWFDTSSDELKVLLPEPFMTFSDYLEGMYEADAKIERESVSELLASGDDLFKKIDEIRNNYSGVEFDVEKFQEFCKELNVNPMLIGHVIEAIFSQKAGVTVTGLGTLSPEMGASVALSSTSVDTCEDMDVTEDMEDIVLMADKSHSYMSPEMARWADVKYGNNKGALVEYKVGTSMTLPATWAEKGKAVLPLSGICVRKPQFSKPLDEEDDLRLSNMNFFKVSDLKLKKTITPVVYTGTIRERQMKNYIDYLSASLGSTLGNLERIVRSDWNGTEESMQTFGLYDCEKCKWLLLPAEKKHAWAVVLASDDTTRIIFLSYDESGSPIIDKKNWKRFAVCSETKVYSVIRSLEVLNKEAIVDPGVHITLVDGVPGCGKTAEIIARVNWKTDLVLTPGREAAAMIRRRACALHKSPVATNDNVRTFDSFVMNRKIFKFDAVYVDEGLMVHTGLLNFALKISGCKKAFVFGDAKQIPFINRVMNFDYPKELRTLIVDNVERRYVTHRCPRDVTSFLNTIYKAAVATTSPVVHSVKAIKVSGAGILRPELTKIKGKIITFTQSDKQSLIKSGYNDVNTVHEIQGETFEETAVVRATPTPIGLIARDSPHVLVALTRHTKAMVYYTVVFDAVTSIIADVEKVDQSILTMFATTVPTKXQLMQNSLYVHRNIFLPVSKTGFYTDMQEFYDRCLPGNSFVLNDFDAVTMRLRDNEFNLQPCRLTLSNLDPVPALIKNEAQNFLIPVLRTACERPRIPGLLENLVAMIKRNMNTPDLAGTVDITNMSISIVDNFFSSFVRDEVLLDHLDCVRASSIQSFSDWFSCQPTSAVGQLANFNFIDLPAFDTYMHMIKRQPKSRLDTSIQSEYPALQTIVYHPKVVNAVFGPVFKYLTTKFLSMVDSSKFFFYTRKKPEDLQEFFSDLSSHSDYEILELDVSKYDKSQSDFHFSIEMAIWEKLGLDDILAWMWSMGHKRTILQDFQAGIKTLIYYQRKSGDVTTFIGNTFIIAACVASMLPLDKCFKASFCGDDSLIYLPKGLEYPDIQATANLVWNFEAKLFRKKYGYFCGKYIIHHANGCIVYPDPLKLISKLGNKSLVGYEHVEEFRISLLDVAHSLFNGAYFHLLDDAIHELFPNAGGCSFVINCLCKYLSDKRLFRSLYIDVSK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D12505
EMBL· GenBank· DDBJ
BAA18895.1
EMBL· GenBank· DDBJ
Genomic RNA
D12505
EMBL· GenBank· DDBJ
BAA18896.1
EMBL· GenBank· DDBJ
Genomic RNA

Genome annotation databases

Similar Proteins

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