P69345 · MTGA_NEIME
- ProteinBiosynthetic peptidoglycan transglycosylase
- GenemtgA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids165 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
Catalytic activity
- [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+
[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate RHEA-COMP:9602 + CHEBI:60033 = [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate RHEA-COMP:9603 + CHEBI:58405 + CHEBI:15378
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | peptidoglycan-based cell wall | |
Cellular Component | plasma membrane | |
Molecular Function | pentosyltransferase activity | |
Molecular Function | peptidoglycan glycosyltransferase activity | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameBiosynthetic peptidoglycan transglycosylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionP69345
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Single-pass membrane protein
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 6 | in allele 2, allele 4, allele 7, allele 8, allele 12 and allele 15 | |||
Natural variant | 9 | in allele 15 | |||
Natural variant | 9 | in allele 1, allele 2, allele 4, allele 7, allele 8, allele 9, allele 10, allele 11, allele 12 and allele 16 | |||
Natural variant | 13 | in allele 1, allele 2, allele 4, allele 7, allele 8, allele 9, allele 10, allele 11, allele 12 and allele 16 | |||
Natural variant | 26 | in allele 4, allele 8, allele 12 and allele 15 | |||
Natural variant | 50 | in allele 10 and allele 15 | |||
Natural variant | 53 | in allele 15 | |||
Natural variant | 75 | in allele 15 | |||
Natural variant | 110 | in allele 15 | |||
Natural variant | 110 | in allele 7 | |||
Natural variant | 122-123 | in allele 15 | |||
Natural variant | 127 | in allele 15 | |||
Natural variant | 129 | in allele 7, allele 8, allele 9, allele 10, allele 11 and allele 14 | |||
Natural variant | 139 | in allele 16 | |||
Natural variant | 144 | in allele 13 | |||
Natural variant | 164 | in allele 5, allele 10, allele 13 and allele 15 | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000083133 | 1-165 | Biosynthetic peptidoglycan transglycosylase | ||
Structure
Sequence
- Sequence statusFragment
- Length165
- Mass (Da)18,786
- Last updated2005-03-01 v1
- Checksum00A7B71CD976BE11
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 165 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF037814 EMBL· GenBank· DDBJ | AAC08817.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037815 EMBL· GenBank· DDBJ | AAC08818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037816 EMBL· GenBank· DDBJ | AAC08819.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037817 EMBL· GenBank· DDBJ | AAC08820.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037818 EMBL· GenBank· DDBJ | AAC08821.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037819 EMBL· GenBank· DDBJ | AAC08822.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037820 EMBL· GenBank· DDBJ | AAC08823.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037821 EMBL· GenBank· DDBJ | AAC08824.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037822 EMBL· GenBank· DDBJ | AAC08825.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037823 EMBL· GenBank· DDBJ | AAC08826.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037824 EMBL· GenBank· DDBJ | AAC08827.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037825 EMBL· GenBank· DDBJ | AAC08828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037826 EMBL· GenBank· DDBJ | AAC08829.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037827 EMBL· GenBank· DDBJ | AAC08830.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037828 EMBL· GenBank· DDBJ | AAC08831.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF037829 EMBL· GenBank· DDBJ | AAC08832.1 EMBL· GenBank· DDBJ | Genomic DNA |