P69215 · COX3_BRALA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Biological Processaerobic electron transport chain

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 3
  • EC number
  • Alternative names
    • Cytochrome c oxidase polypeptide III

Gene names

    • Name
      COIII

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    P69215
  • Secondary accessions
    • O47425

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane11-31Helical
Transmembrane32-52Helical
Transmembrane83-103Helical
Transmembrane125-147Helical
Transmembrane160-180Helical
Transmembrane198-218Helical
Transmembrane240-260Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001837481-262Cytochrome c oxidase subunit 3

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    262
  • Mass (Da)
    29,711
  • Last updated
    2005-02-15 v1
  • Checksum
    6D93D8338AC870D8
MTGYQPHPWHLVEPSPWPLVGGSAAFTLTVGLVMWFHYNSISLMILGLVMIVATMIQWWRDVIREATFQGCHTSYVLSGLRRGMVLFIVSEVFFFLAFFWAFFHSSLAPTVELGVTWPPVGVHPLNAFAVPLLNTAVLLSSGVTVTWAHHALMEGKRTEAIQSLAITVMLGLYFTGLQAWEYYEAPFTIADSVYGSTFFVATGFHGLHVIIGSTFLMVCLGRQVFYHYTSSHHFGFEAAAWYWHFVDVVWLFLYVCIYWWGS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y16474
EMBL· GenBank· DDBJ
CAA76253.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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