P69180 · IAP_ASFB7

Function

function

Prevent apoptosis of host cell by inhibiting caspase-3/CASP3 activation to promote the viral replication. Induces also the activation of host NF-kappaB.

Features

Showing features for binding site.

122420406080100120140160180200220
TypeIDPosition(s)Description
Binding site62Zn2+ (UniProtKB | ChEBI)
Binding site65Zn2+ (UniProtKB | ChEBI)
Binding site82Zn2+ (UniProtKB | ChEBI)
Binding site89Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componentvirion component
Molecular Functionmetal ion binding
Biological Processsymbiont-mediated activation of host NF-kappaB cascade
Biological Processsymbiont-mediated perturbation of host apoptosis
Biological Processsymbiont-mediated suppression of host apoptosis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Inhibitor of apoptosis protein
  • Short names
    IAP

Gene names

    • ORF names
      4CL, A224L
    • Ordered locus names
      BA71V-032

Organism names

Accessions

  • Primary accession
    P69180
  • Secondary accessions
    • O12627
    • O12628
    • O12629
    • O12630
    • O12631

Proteomes

Subcellular Location

Host cytoplasm
Virion
Note: Probably accumulates in the perinuclear cytoplasmic viral factories. Found in association with viral nucleoid (PubMed:30185597).

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001223731-224Inhibitor of apoptosis protein

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with subunit p17 of host CASP3.

Structure

3D structure databases

Family & Domains

Features

Showing features for repeat, zinc finger.

Type
IDPosition(s)Description
Repeat29-92BIR
Zinc finger189-207C4-type

Sequence similarities

Belongs to the asfivirus IAP family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    224
  • Mass (Da)
    26,618
  • Last updated
    2005-02-15 v1
  • MD5 Checksum
    595C4D1CD936C32A37E45A86E5C0E5DA
MFPKINTIDPYISLRLFEVKPKYVGYSSIDARNQSFAIHGIKNYEKFSNAGFFYTSPTEITCYCCGMKFCNWLYEKHPLQVHGFWSRNCGFMRATLGIIGLKKMIDSYNDYYNNEVFVKHKNRVYTHKRLEDMGFSKPFMRFILANAFIPPYRKYIHKIILNERYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U18466
EMBL· GenBank· DDBJ
AAA65263.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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