P68501 · MTB_ONCMY

Function

function

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

Features

Showing features for binding site.

16051015202530354045505560
MDPCECSKTGSCNCGGSCKCSNCACTSCKKSCCPCCPSDCSKCASGCVCKGKTCDTSCCQ
TypeIDPosition(s)Description
Binding site4a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site6a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site6a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site12a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site14a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site14a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site18a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site20a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site23a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site23a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site25a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site28a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site32a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site33a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site33a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site35a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site36a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site36a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site40a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site43a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site43a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site47a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site49a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site49a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site54a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site58a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site59a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site59a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Biological Processresponse to cadmium ion
Biological Processresponse to copper ion
Biological Processresponse to mercury ion
Biological Processresponse to zinc ion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Metallothionein B
  • Short names
    MT-B

Gene names

    • Name
      mtb

Organism names

Accessions

  • Primary accession
    P68501
  • Secondary accessions
    • P09862

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001972961-60Metallothionein B

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-28Beta
Region29-60Alpha

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    60
  • Mass (Da)
    6,033
  • Last updated
    2004-11-23 v1
  • Checksum
    9EA1E70FBE59B4EE
MDPCECSKTGSCNCGGSCKCSNCACTSCKKSCCPCCPSDCSKCASGCVCKGKTCDTSCCQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M18104
EMBL· GenBank· DDBJ
AAA49566.1
EMBL· GenBank· DDBJ
mRNA
M22487
EMBL· GenBank· DDBJ
AAA49567.1
EMBL· GenBank· DDBJ
Genomic DNA
X59394
EMBL· GenBank· DDBJ
CAA42037.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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