P68500 · CNTN5_MOUSE

  • Protein
    Contactin-5
  • Gene
    Cntn5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons (By similarity).
Involved in neuronal activity in the auditory system

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular ComponentGABA-ergic synapse
Cellular Componentplasma membrane
Cellular Componentpresynaptic membrane
Cellular Componentside of membrane
Cellular Componentsynapse
Molecular Functioncell-cell adhesion mediator activity
Biological Processaxon guidance
Biological Processdendrite self-avoidance
Biological Processhomophilic cell adhesion via plasma membrane adhesion molecules
Biological Processpresynapse assembly
Biological Processsensory perception of sound
Biological Processsynapse organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Contactin-5
  • Alternative names
    • Neural recognition molecule NB-2

Gene names

    • Name
      Cntn5

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P68500
  • Secondary accessions
    • E0CYC2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_000001471924-1071Contactin-5
Disulfide bond122↔172
Glycosylation137N-linked (GlcNAc...) asparagine
Glycosylation195N-linked (GlcNAc...) asparagine
Disulfide bond216↔268
Disulfide bond321↔368
Glycosylation396N-linked (GlcNAc...) asparagine
Disulfide bond410↔457
Glycosylation448N-linked (GlcNAc...) asparagine
Disulfide bond502↔550
Glycosylation539N-linked (GlcNAc...) asparagine
Disulfide bond592↔649
Glycosylation778N-linked (GlcNAc...) asparagine
Glycosylation815N-linked (GlcNAc...) asparagine
Glycosylation930N-linked (GlcNAc...) asparagine
Glycosylation1001N-linked (GlcNAc...) asparagine
Lipidation1071GPI-anchor amidated serine
PropeptidePRO_00000147201072-1098Removed in mature form

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the nervous system. Preferentially expressed in the central auditory pathways.

Developmental stage

Specifically expressed in the postnatal nervous system, reaching a maximum level at 3 weeks postnatal.

Gene expression databases

Interaction

Subunit

Interacts with PTPRG.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain98-189Ig-like C2-type 1
Domain195-281Ig-like C2-type 2
Domain299-384Ig-like C2-type 3
Domain389-473Ig-like C2-type 4
Domain479-568Ig-like C2-type 5
Domain570-659Ig-like C2-type 6
Domain672-770Fibronectin type-III 1
Domain775-872Fibronectin type-III 2
Domain877-971Fibronectin type-III 3
Region956-982Disordered
Domain976-1066Fibronectin type-III 4

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,098
  • Mass (Da)
    120,746
  • Last updated
    2011-07-27 v2
  • Checksum
    201929C9C7C5C3C8
MASCWRLILFLSVTRWLSDYSEALSGLSTSYAALLRIKKSSTSPFGSKSRPRFSSPSLGTISVSPPSWRGAAQQYHSPGNLYHSSDAFRQDESVDYGPVFVQEPDDVIFPTDSDEKKVALNCEVRGNPSPSYRWLRNGTEIALESDYRYSLIDGTFIISNPSELRDSGLYQCLATNSFGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNAVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKSRLRKSQAVLEIPNLQLDDAGIYECTAENSRGKNSFRGQLQIFTYPHWVQKLNDTQLDSGSPLQWECKATGKPRPTYRWLKNGAPLLPQSRVDTVNGILAIQSVNQSDAGMYQCLAENKYGAIYASAELKILASPPSFELNQVKKSIIVTKDRGVLIECEPQGSPKPAISWRKGDKAVRANKRIAILPDGSLRILNASKADEGKYICQGVNIFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEKEGGHFENIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGVVIVEEITESTATLSWSPATDNHSPISSYNLQARSPFSLGWQTVKTVPEVITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSIPSRMIRTNEAVPKTAPSNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPTAAPTDVTATSVSVSEIFVVWKHVKESLGRPQGFEISYWKDTEPEDSVETVRTRGNESFVMLTGLEGNTLYHLTVRAYNGAGYGPPSREASTTTKRHPPREPPGNLRWEQQGSQVSLGWEPVRPLANESEVMGYKVFYRQEGHSEGQVIETQKPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSLSKWSSVTLLLALMLPSSSW

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E9PYK7E9PYK7_MOUSECntn5893

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC100491
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC102350
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC107635
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC113470
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC117684
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC118029
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC153417
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC154645
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC154651
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CT033779
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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