P68500 · CNTN5_MOUSE
- ProteinContactin-5
- GeneCntn5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1098 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons (By similarity).
Involved in neuronal activity in the auditory system
Involved in neuronal activity in the auditory system
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | GABA-ergic synapse | |
Cellular Component | plasma membrane | |
Cellular Component | presynaptic membrane | |
Cellular Component | side of membrane | |
Cellular Component | synapse | |
Molecular Function | cell-cell adhesion mediator activity | |
Biological Process | axon guidance | |
Biological Process | dendrite self-avoidance | |
Biological Process | homophilic cell adhesion via plasma membrane adhesion molecules | |
Biological Process | presynapse assembly | |
Biological Process | sensory perception of sound | |
Biological Process | synapse organization |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameContactin-5
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP68500
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MASCWRLILFLSVTRWLSDYSEA | ||||||
Chain | PRO_0000014719 | 24-1071 | Contactin-5 | |||
Sequence: LSGLSTSYAALLRIKKSSTSPFGSKSRPRFSSPSLGTISVSPPSWRGAAQQYHSPGNLYHSSDAFRQDESVDYGPVFVQEPDDVIFPTDSDEKKVALNCEVRGNPSPSYRWLRNGTEIALESDYRYSLIDGTFIISNPSELRDSGLYQCLATNSFGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNAVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKSRLRKSQAVLEIPNLQLDDAGIYECTAENSRGKNSFRGQLQIFTYPHWVQKLNDTQLDSGSPLQWECKATGKPRPTYRWLKNGAPLLPQSRVDTVNGILAIQSVNQSDAGMYQCLAENKYGAIYASAELKILASPPSFELNQVKKSIIVTKDRGVLIECEPQGSPKPAISWRKGDKAVRANKRIAILPDGSLRILNASKADEGKYICQGVNIFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEKEGGHFENIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGVVIVEEITESTATLSWSPATDNHSPISSYNLQARSPFSLGWQTVKTVPEVITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSIPSRMIRTNEAVPKTAPSNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPTAAPTDVTATSVSVSEIFVVWKHVKESLGRPQGFEISYWKDTEPEDSVETVRTRGNESFVMLTGLEGNTLYHLTVRAYNGAGYGPPSREASTTTKRHPPREPPGNLRWEQQGSQVSLGWEPVRPLANESEVMGYKVFYRQEGHSEGQVIETQKPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITS | ||||||
Disulfide bond | 122↔172 | |||||
Sequence: CEVRGNPSPSYRWLRNGTEIALESDYRYSLIDGTFIISNPSELRDSGLYQC | ||||||
Glycosylation | 137 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 195 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 216↔268 | |||||
Sequence: CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYIC | ||||||
Disulfide bond | 321↔368 | |||||
Sequence: CFALGNPVPTITWMKVNGYIPSKSRLRKSQAVLEIPNLQLDDAGIYEC | ||||||
Glycosylation | 396 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 410↔457 | |||||
Sequence: CKATGKPRPTYRWLKNGAPLLPQSRVDTVNGILAIQSVNQSDAGMYQC | ||||||
Glycosylation | 448 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 502↔550 | |||||
Sequence: CEPQGSPKPAISWRKGDKAVRANKRIAILPDGSLRILNASKADEGKYIC | ||||||
Glycosylation | 539 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 592↔649 | |||||
Sequence: CKAIHDASLDVTFYWTLKGQPIDFEKEGGHFENIRAQASSADLMIRNILLMHAGRYGC | ||||||
Glycosylation | 778 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 815 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 930 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1001 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Lipidation | 1071 | GPI-anchor amidated serine | ||||
Sequence: S | ||||||
Propeptide | PRO_0000014720 | 1072-1098 | Removed in mature form | |||
Sequence: AQSTLHSLSKWSSVTLLLALMLPSSSW |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the nervous system. Preferentially expressed in the central auditory pathways.
Developmental stage
Specifically expressed in the postnatal nervous system, reaching a maximum level at 3 weeks postnatal.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 98-189 | Ig-like C2-type 1 | ||||
Sequence: PVFVQEPDDVIFPTDSDEKKVALNCEVRGNPSPSYRWLRNGTEIALESDYRYSLIDGTFIISNPSELRDSGLYQCLATNSFGSILSREATLQ | ||||||
Domain | 195-281 | Ig-like C2-type 2 | ||||
Sequence: NFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNAVTNARVLS | ||||||
Domain | 299-384 | Ig-like C2-type 3 | ||||
Sequence: PKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKSRLRKSQAVLEIPNLQLDDAGIYECTAENSRGKNSFRGQLQ | ||||||
Domain | 389-473 | Ig-like C2-type 4 | ||||
Sequence: PHWVQKLNDTQLDSGSPLQWECKATGKPRPTYRWLKNGAPLLPQSRVDTVNGILAIQSVNQSDAGMYQCLAENKYGAIYASAELK | ||||||
Domain | 479-568 | Ig-like C2-type 5 | ||||
Sequence: PSFELNQVKKSIIVTKDRGVLIECEPQGSPKPAISWRKGDKAVRANKRIAILPDGSLRILNASKADEGKYICQGVNIFGSAEIIASLSVK | ||||||
Domain | 570-659 | Ig-like C2-type 6 | ||||
Sequence: PTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEKEGGHFENIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVS | ||||||
Domain | 672-770 | Fibronectin type-III 1 | ||||
Sequence: PPGVVIVEEITESTATLSWSPATDNHSPISSYNLQARSPFSLGWQTVKTVPEVITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSIPSRMIRTNEA | ||||||
Domain | 775-872 | Fibronectin type-III 2 | ||||
Sequence: APSNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEG | ||||||
Domain | 877-971 | Fibronectin type-III 3 | ||||
Sequence: APTDVTATSVSVSEIFVVWKHVKESLGRPQGFEISYWKDTEPEDSVETVRTRGNESFVMLTGLEGNTLYHLTVRAYNGAGYGPPSREASTTTKRH | ||||||
Region | 956-982 | Disordered | ||||
Sequence: GYGPPSREASTTTKRHPPREPPGNLRW | ||||||
Domain | 976-1066 | Fibronectin type-III 4 | ||||
Sequence: PPGNLRWEQQGSQVSLGWEPVRPLANESEVMGYKVFYRQEGHSEGQVIETQKPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQIRVPSYSG |
Sequence similarities
Belongs to the immunoglobulin superfamily. Contactin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,098
- Mass (Da)120,746
- Last updated2011-07-27 v2
- Checksum201929C9C7C5C3C8
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E9PYK7 | E9PYK7_MOUSE | Cntn5 | 893 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC100491 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC102350 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC107635 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC113470 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC117684 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC118029 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC153417 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC154645 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC154651 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CT033779 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |