P68253 · 1433G_SHEEP

  • Protein
    14-3-3 protein gamma
  • Gene
    YWHAG
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24. Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1.

Features

Showing features for site.

115820406080100120140
TypeIDPosition(s)Description
Site34Interaction with phosphoserine on interacting protein
Site59Interaction with phosphoserine on interacting protein

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functioninsulin-like growth factor receptor binding
Molecular Functionphosphorylation-dependent protein binding
Molecular Functionprotein kinase C binding
Molecular Functionprotein sequestering activity
Biological Processpositive regulation of cell-cell adhesion
Biological Processregulation of neuron differentiation
Biological Processregulation of protein localization
Biological Processregulation of synaptic plasticity
Biological Processsignal transduction

Names & Taxonomy

Protein names

  • Recommended name
    14-3-3 protein gamma
  • Alternative names
    • Protein kinase C inhibitor protein 1 (KCIP-1)

Gene names

    • Name
      YWHAG

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis

Accessions

  • Primary accession
    P68253
  • Secondary accessions
    • P29359

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000586101-15814-3-3 protein gamma
Modified residue48Phosphoserine
Modified residue60Phosphotyrosine
Modified residue72Phosphothreonine
Modified residue130Phosphoserine
Modified residue149Phosphothreonine
Modified residue150Phosphoserine

Post-translational modification

Phosphorylated by various PKC isozymes.

Keywords

Interaction

Subunit

Homodimer (By similarity).
Interacts with SAMSN1 (By similarity).
Interacts with RAF1, SSH1 and CRTC2/TORC2 (By similarity).
Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity).
Interacts with GAB2 (By similarity).
Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53 (By similarity).
Interacts with PKA-phosphorylated AANAT and SIRT2 (PubMed:11427721).
Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity).
Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity).
Interacts with SLITRK1 (By similarity).
Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (By similarity).
Interacts with MARK2 and MARK3 (By similarity).
Interacts with MEFV (By similarity).
Interacts with ENDOG, TSC2 and PIK3C3; interaction with ENDOG weakens its interaction with TSC2 and PIK3C3 (By similarity).
Interacts with (phosphorylated) WDR24 (By similarity).
Interacts with BEST1; this interaction promotes L-glutamate channel activity leading to the positive regulation of NMDA glutamate receptor activity through the L-glutamate secretion (By similarity).

Structure

Family & Domains

Sequence similarities

Belongs to the 14-3-3 family.

Family and domain databases

Sequence

  • Sequence status
    Fragments
  • Length
    158
  • Mass (Da)
    18,000
  • Last updated
    2004-10-25 v1
  • Checksum
    69EC73EBA23B7B6F
AAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEITAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGG

Features

Showing features for non-terminal residue, non-adjacent residues.

TypeIDPosition(s)Description
Non-terminal residue1
Non-adjacent residues48-49
Non-adjacent residues113-114
Non-terminal residue158

Keywords

Sequence databases

Similar Proteins

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