P68012 · HBB_URSTH

Function

function

Involved in oxygen transport from the lung to the various peripheral tissues.

Features

Showing features for binding site.

114620406080100120140
TypeIDPosition(s)Description
Binding site63Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); distal binding residue
Binding site92Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); proximal binding residue

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentblood microparticle
Cellular Componenthaptoglobin-hemoglobin complex
Cellular Componenthemoglobin complex
Molecular Functionhaptoglobin binding
Molecular Functionheme binding
Molecular Functionhemoglobin alpha binding
Molecular Functionmetal ion binding
Molecular Functionorganic acid binding
Molecular Functionoxygen binding
Molecular Functionoxygen carrier activity
Molecular Functionperoxidase activity
Biological Processhydrogen peroxide catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hemoglobin subunit beta
  • Alternative names
    • Beta-globin
    • Hemoglobin beta chain

Gene names

    • Name
      HBB

Organism names

Accessions

  • Primary accession
    P68012
  • Secondary accessions
    • P07422

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylvaline
ChainPRO_00000531491-146Hemoglobin subunit beta
Modified residue12Phosphothreonine
Modified residue44Phosphoserine
Modified residue59N6-acetyllysine
Modified residue82N6-acetyllysine
Modified residue93S-nitrosocysteine
Modified residue144N6-acetyllysine

Keywords

Expression

Tissue specificity

Red blood cells.

Interaction

Subunit

Heterotetramer of two alpha chains and two beta chains.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-146Globin

Sequence similarities

Belongs to the globin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    146
  • Mass (Da)
    16,009
  • Last updated
    1988-04-01 v1
  • Checksum
    41A93E4F3E98CE3C
VHLTGEEKSLVTGLWGKVNVDEVGGEALGRLLVVYPWTQRFFDSFGDLSSADAIMNNPKVKAHGKKVLNSFSDGLKNLDNLKGTFAKLSELHCDKLHVDPENFKLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVANALAHKYH

Keywords

Sequence databases

Similar Proteins

Disclaimer

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