P67971 · INS_SAISC

Function

function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionhormone activity
Molecular Functioninsulin receptor binding
Biological Processcellular response to oxygen-containing compound
Biological Processglucose homeostasis
Biological Processglucose metabolic process
Biological Processpositive regulation of protein secretion

Keywords

Names & Taxonomy

Protein names

Gene names

    • Name
      INS

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Saimiriinae > Saimiri

Accessions

  • Primary accession
    P67971
  • Secondary accessions
    • P10604

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for peptide, disulfide bond.

TypeIDPosition(s)Description
PeptidePRO_00000159041-30Insulin B chain
Disulfide bond7↔37Interchain (between B and A chains)
Disulfide bond19↔50Interchain (between B and A chains)
PeptidePRO_000001590531-51Insulin A chain
Disulfide bond36↔41

Keywords

Interaction

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Structure

Family & Domains

Sequence similarities

Belongs to the insulin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    51
  • Mass (Da)
    5,747
  • Last updated
    2004-10-11 v1
  • Checksum
    84572881D72E7D6D
FVNQHLCGPHLVEALYLVCGERGFFYAPKTGVVDQCCTSICSLYQLQNYCN

Features

Showing features for non-adjacent residues.

TypeIDPosition(s)Description
Non-adjacent residues30-31

Keywords

Similar Proteins

Disclaimer

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