P67963 · KC1A_XENLA

Function

function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly (By similarity) (PubMed:9022677).
Phosphorylates protein custos (PubMed:25157132).

Catalytic activity

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site23-31ATP (UniProtKB | ChEBI)
Binding site46ATP (UniProtKB | ChEBI)
Active site136Proton acceptor

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentciliary basal body
Cellular Componentcytoplasm
Cellular Componentkinetochore
Cellular Componentnuclear speck
Cellular Componentspindle
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processcell division
Biological Processintermediate filament cytoskeleton organization
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of NLRP3 inflammasome complex assembly
Biological Processpeptidyl-serine phosphorylation
Biological Processprotein phosphorylation
Biological ProcessWnt signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Casein kinase I isoform alpha
  • EC number
  • Short names
    CKI-alpha
  • Alternative names
    • CK1

Gene names

    • Name
      csnk1a1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    P67963
  • Secondary accessions
    • O57528
    • P70065
    • P79789
    • P79790
    • Q5D074

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001928291-337Casein kinase I isoform alpha

Post-translational modification

Autophosphorylated.

Keywords

Expression

Gene expression databases

    • 379624Expressed in gastrula and 19 other cell types or tissues

Interaction

Subunit

Interacts with custos.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain17-285Protein kinase
Region309-337Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    337
  • Mass (Da)
    38,901
  • Last updated
    2004-10-11 v1
  • Checksum
    002085AE33CAFAC6
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKSKSNMKGF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y08817
EMBL· GenBank· DDBJ
CAA70051.1
EMBL· GenBank· DDBJ
mRNA
BC057701
EMBL· GenBank· DDBJ
AAH57701.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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