P64300 · GUAA_STRP8
- ProteinGMP synthase [glutamine-hydrolyzing]
- GeneguaA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids520 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the synthesis of GMP from XMP.
Catalytic activity
- XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H+
Pathway
Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 89 | Nucleophile | |||
Active site | 179 | ||||
Active site | 181 | ||||
Binding site | 233-239 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | GMP synthase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGMP synthase [glutamine-hydrolyzing]
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillati > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionP64300
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000140193 | 1-520 | GMP synthase [glutamine-hydrolyzing] | ||
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length520
- Mass (Da)57,502
- Last updated2004-10-11 v1
- MD5 ChecksumF3A3FDA35A0659C8B62073B5ECF95AB2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE009949 EMBL· GenBank· DDBJ | AAL97771.1 EMBL· GenBank· DDBJ | Genomic DNA |