P64105 · FABA_SALTY
- Protein3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
- GenefabA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids172 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-2-decenoyl-ACP and then its isomerization to Z-3-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
Catalytic activity
- a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O
- (3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 71 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity | |
Molecular Function | trans-2-decenoyl-acyl-carrier-protein isomerase activity | |
Biological Process | unsaturated fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionP64105
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000091614 | 2-172 | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase | |||
Sequence: VDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTARKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTAHDLKVGLFQDTSAF |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length172
- Mass (Da)19,047
- Last updated2007-01-23 v2
- ChecksumDFD69583E5C0782C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE006468 EMBL· GenBank· DDBJ | AAL20000.1 EMBL· GenBank· DDBJ | Genomic DNA |