T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-theta-mediated phosphorylation of RanGAP1.
Brucella 16M activated SUMO1/Ubc9 expression in a time-dependent manner and Brucella 16M intracellular survival was inhibited by SUMO1/Ubc9 overexpression and promoted by SUMO1/Ubc9 depletion.
Our data uncovers an important role of SUMO1 in VSMCs proliferation migration autophagy and phenotypic switching (dedifferentiation) involved in pulmonary vascular remodeling and pulmonary arterial hypertension
miR-146a is a novel regulator of the SUMOylation machinery in the heart down-regulating SUMO1 expression and inducing cardiac dysfunction in maladaptive cardiac hypertrophy.
integrity is required for PLK1 localization with SUMO-1 but not with SUMO-2/3. Inhibition of SUMOylation disrupts proper meiotic bipolar spindle organization and spindle-kinetochore attachment.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.