P63124 · VPK04_HUMAN

  • Protein
    Endogenous retrovirus group K member 104 Pro protein
  • Gene
    HERV-K104
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution (By similarity).

Catalytic activity

  • Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.
    EC:3.4.23.50 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

115620406080100120140
TypeIDPosition(s)Description
Active site26

GO annotations

AspectTerm
Molecular Functionaspartic-type endopeptidase activity
Molecular Functionnucleic acid binding
Biological Processproteolysis
Biological Processviral translational frameshifting

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Endogenous retrovirus group K member 104 Pro protein
  • Alternative names
    • HERV-K104 Pro protein
    • HERV-K_5q13.3 provirus ancestral Pro protein (EC:3.4.23.50) . EC:3.4.23.50 (UniProtKB | ENZYME | Rhea)
    • Protease
    • Proteinase (PR)

Gene names

    • Name
      HERV-K104

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P63124

Proteomes

Organism-specific databases

Disease & Variants

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001995431-156Endogenous retrovirus group K member 104 Pro protein

Post-translational modification

Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).

Proteomic databases

PTM databases

Interaction

Subunit

Active as a homodimer.

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-96Peptidase A2
Domain111-156G-patch

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete

This entry describes 1 isoforms produced by Ribosomal frameshifting. This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.

P63124-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    156
  • Mass (Da)
    17,121
  • Last updated
    2004-09-13 v1
  • Checksum
    C8C3A3AF2B056761
WASQVSENRPVCKAIIQGKQFEGLVDTEADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGQDLLQQWGAEITMPAPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKVPVEAKINQKREGIGYPF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF164612
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

Disclaimer

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