P63030 · MPC1_MOUSE

  • Protein
    Mitochondrial pyruvate carrier 1
  • Gene
    Mpc1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Mediates the uptake of pyruvate into mitochondria.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Molecular Functionpyruvate transmembrane transporter activity
Biological Processacetyl-CoA biosynthetic process from pyruvate
Biological Processcellular response to leukemia inhibitory factor
Biological Processmitochondrial pyruvate transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial pyruvate carrier 1
  • Alternative names
    • Brain protein 44-like protein

Gene names

    • Name
      Mpc1
    • Synonyms
      Brp44l

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P63030
  • Secondary accessions
    • Q9D6C0
    • Q9JLG5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain2-20Mitochondrial matrix
Transmembrane21-41Helical
Topological domain42-52Mitochondrial intermembrane
Transmembrane53-71Helical
Topological domain72-109Mitochondrial matrix

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 7 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00002127982-109Mitochondrial pyruvate carrier 1
Modified residue72N6-acetyllysine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Forms heterodimer with MPC2. The heterodimer is the more stable and dominant form.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence

  • Sequence status
    Complete
  • Length
    109
  • Mass (Da)
    12,455
  • Last updated
    2004-08-31 v1
  • Checksum
    E0536878BAA68124
MAGALVRKAADYVRSKDFRDYLMSTHFWGPVANWGLPIAAINDMKKSPEIISGRMTFALCCYSLTFMRFAYKVQPRNWLLFACHVTNEVAQLIQGGRLINYEMSKRPSA

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9Q0V4E9Q0V4_MOUSEMpc1167
D3Z786D3Z786_MOUSEMpc178
D3Z5S0D3Z5S0_MOUSEMpc186
D3YWY6D3YWY6_MOUSEMpc185

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict64in Ref. 2; BAB29340

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF181116
EMBL· GenBank· DDBJ
AAF25816.1
EMBL· GenBank· DDBJ
mRNA
AK002241
EMBL· GenBank· DDBJ
BAB21958.1
EMBL· GenBank· DDBJ
mRNA
AK002266
EMBL· GenBank· DDBJ
BAB21976.1
EMBL· GenBank· DDBJ
mRNA
AK004013
EMBL· GenBank· DDBJ
BAB23124.1
EMBL· GenBank· DDBJ
mRNA
AK013391
EMBL· GenBank· DDBJ
BAB28826.1
EMBL· GenBank· DDBJ
mRNA
AK014421
EMBL· GenBank· DDBJ
BAB29340.1
EMBL· GenBank· DDBJ
mRNA
BC024365
EMBL· GenBank· DDBJ
AAH24365.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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