P63006 · LHX1_MOUSE

  • Protein
    LIM/homeobox protein Lhx1
  • Gene
    Lhx1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.

Features

Showing features for dna binding.

140650100150200250300350400
TypeIDPosition(s)Description
DNA binding180-239Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Cellular Componenttranscription regulator complex
Molecular Functioncis-regulatory region sequence-specific DNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processanatomical structure formation involved in morphogenesis
Biological Processanatomical structure morphogenesis
Biological Processanterior/posterior axis specification
Biological Processanterior/posterior pattern specification
Biological Processbranching involved in ureteric bud morphogenesis
Biological Processcell differentiation
Biological Processcell-cell signaling
Biological Processcellular response to fibroblast growth factor stimulus
Biological Processcerebellar Purkinje cell differentiation
Biological Processcerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
Biological Processcerebellum development
Biological Processcervix development
Biological Processcomma-shaped body morphogenesis
Biological Processdorsal/ventral pattern formation
Biological Processectoderm formation
Biological Processembryonic pattern specification
Biological Processembryonic retina morphogenesis in camera-type eye
Biological Processembryonic viscerocranium morphogenesis
Biological Processendoderm development
Biological Processendoderm formation
Biological Processepithelium development
Biological Processforebrain regionalization
Biological Processgastrulation with mouth forming second
Biological Processhead development
Biological Processkidney development
Biological Processlateral motor column neuron migration
Biological Processmesendoderm development
Biological Processmesonephric duct development
Biological Processmesonephros development
Biological Processmetanephric comma-shaped body morphogenesis
Biological Processmetanephric glomerulus development
Biological Processmetanephric part of ureteric bud development
Biological Processmetanephric renal vesicle morphogenesis
Biological Processmetanephric S-shaped body morphogenesis
Biological Processmetanephros development
Biological Processmotor neuron axon guidance
Biological Processnegative regulation of DNA-templated transcription
Biological Processnephric duct elongation
Biological Processnephric duct morphogenesis
Biological Processneuron differentiation
Biological Processoviduct development
Biological Processoviduct epithelium development
Biological Processparamesonephric duct development
Biological Processpattern specification process
Biological Processpositive regulation of anterior head development
Biological Processpositive regulation of branching involved in ureteric bud morphogenesis
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of embryonic development
Biological Processpositive regulation of gastrulation
Biological Processpositive regulation of nephron tubule epithelial cell differentiation
Biological Processpost-embryonic development
Biological Processprimitive streak formation
Biological Processpronephros development
Biological Processregulation of gene expression
Biological Processregulation of transcription by RNA polymerase II
Biological Processrenal vesicle morphogenesis
Biological Processretina development in camera-type eye
Biological Processretina layer formation
Biological ProcessS-shaped body morphogenesis
Biological Processsomite rostral/caudal axis specification
Biological Processspinal cord association neuron differentiation
Biological Processspinal cord development
Biological Processtelencephalon development
Biological Processtranscription by RNA polymerase II
Biological Processureter morphogenesis
Biological Processureteric bud development
Biological Processurogenital system development
Biological Processuterine epithelium development
Biological Processuterus development
Biological Processvagina development
Biological Processventral spinal cord development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    LIM/homeobox protein Lhx1
  • Short names
    LIM homeobox protein 1
  • Alternative names
    • Homeobox protein Lim-1

Gene names

    • Name
      Lhx1
    • Synonyms
      Lim-1, Lim1

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • 129/SvEv
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P63006
  • Secondary accessions
    • P36199

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis28Disrupts LDB1-binding; when associated with G-88.
Mutagenesis88Disrupts LDB1-binding; when associated with G-28.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000757711-406LIM/homeobox protein Lhx1
Modified residue162Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In mid to late stage embryos, expressed in a restricted region of mesoderm in the primitive streak. At 7.5 days, expressed in a horseshoe shape at the periphery of the node, as well as along both sides of the adjacent notochord. Also present in presumptive lateral and intermediate mesoderm. Later, expression become progressively restricted to intermediate mesoderm, and the developing excretory system including the pronephric region, mesonephros, nephric duct and metanephros. In the metanephros, strongly expressed in renal vesicles and S-shaped and coma-shaped bodies, as well as in the ureteric bud and its derivatives. Also expressed in the dorsal root ganglia. By stage 10.5, also expressed in regions of the central nervous system in the telencephalon through to the spinal cord. In adults, expressed in the cerebellum/medulla and kidney, and at very low levels in the cerebrum.

Developmental stage

Expressed in both embryos and adults.

Gene expression databases

Interaction

Subunit

Interacts with LDB1 via the tandem LIM domains.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain4-54LIM zinc-binding 1
Domain63-117LIM zinc-binding 2
Compositional bias128-147Polar residues
Region128-189Disordered
Compositional bias148-179Basic and acidic residues
Region294-372Disordered
Compositional bias297-313Polar residues

Domain

The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox (By similarity).

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    406
  • Mass (Da)
    44,780
  • Last updated
    2004-08-31 v1
  • Checksum
    CC8637984998ADAF
MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEGGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLDHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGASYGNHLSHPPEMNEAAVW

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0A0MQA9A0A0A0MQA9_MOUSELhx1112
A0A087WNK8A0A087WNK8_MOUSELhx1315

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict12in Ref. 2
Sequence conflict24-31in Ref. 2; AAC60669
Compositional bias128-147Polar residues
Compositional bias148-179Basic and acidic residues
Sequence conflict236in Ref. 2; AAC60669
Compositional bias297-313Polar residues
Sequence conflict335in Ref. 2; AAC60669

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z27410
EMBL· GenBank· DDBJ
CAA81797.1
EMBL· GenBank· DDBJ
mRNA
S68107
EMBL· GenBank· DDBJ
AAC60669.2
EMBL· GenBank· DDBJ
mRNA
AF039706
EMBL· GenBank· DDBJ
AAD02169.1
EMBL· GenBank· DDBJ
Genomic DNA
AF039705
EMBL· GenBank· DDBJ
AAD02169.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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