P62903 · COW_CONMR
- ProteinGlacontryphan-M
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Inhibits high (L-type) voltage-activated calcium channels (Cav) in a calcium-dependent manner.
Miscellaneous
In contrast to the other contryphans, glacontryphan-M is a single homogenous conformer exhibiting no cis to trans isomerization of the Cys-Pro peptidyl bond in aqueous solution.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | calcium channel regulator activity | |
Molecular Function | ion channel inhibitor activity | |
Molecular Function | metal ion binding | |
Molecular Function | toxin activity |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGlacontryphan-M
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Caenogastropoda > Neogastropoda > Conoidea > Conidae > Conus > Conus
Accessions
- Primary accessionP62903
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, propeptide, peptide, modified residue, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MGKLTILVLVAAVLLSTQVMVQG | ||||||
Propeptide | PRO_0000035066 | 24-51 | ||||
Sequence: DRDQPADRNAVPRDDNPGRARRKRMKVL | ||||||
Peptide | PRO_0000035067 | 52-62 | Glacontryphan-M | |||
Sequence: NESECPWHPWC | ||||||
Modified residue | 53 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 55 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Disulfide bond | 56↔62 | |||||
Sequence: CPWHPWC | ||||||
Modified residue | 58 | D-tryptophan | ||||
Sequence: W | ||||||
Modified residue | 62 | Cysteine amide | ||||
Sequence: C |
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom duct.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 23-48 | Disordered | ||||
Sequence: GDRDQPADRNAVPRDDNPGRARRKRM | ||||||
Compositional bias | 29-48 | Basic and acidic residues | ||||
Sequence: ADRNAVPRDDNPGRARRKRM |
Domain
The cysteine framework is C-C.
Sequence similarities
Belongs to the O2 superfamily. Contryphan family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length63
- Mass (Da)7,097
- Last updated2004-08-31 v1
- ChecksumE7F51B5DBB2B1FE1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 29-48 | Basic and acidic residues | ||||
Sequence: ADRNAVPRDDNPGRARRKRM |
Mass Spectrometry
Keywords
- Technical term