P62839 · UB2D2_RAT

  • Protein
    Ubiquitin-conjugating enzyme E2 D2
  • Gene
    Ube2d2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3 (By similarity).
Mediates ubiquitination of PEX5

Catalytic activity

  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
    EC:2.3.2.23 (UniProtKB | ENZYME | Rhea)
  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N6-monoubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.24 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site85Glycyl thioester intermediate

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Cellular Componentubiquitin ligase complex
Molecular FunctionATP binding
Molecular Functionubiquitin conjugating enzyme activity
Molecular Functionubiquitin protein ligase activity
Molecular Functionubiquitin protein ligase binding
Molecular Functionubiquitin-protein transferase activity
Biological Processprotein autoubiquitination
Biological Processprotein K48-linked ubiquitination
Biological Processprotein polyubiquitination
Biological Processprotein ubiquitination
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin-conjugating enzyme E2 D2
  • EC number
  • Alternative names
    • (E3-independent) E2 ubiquitin-conjugating enzyme D2 (EC:2.3.2.24) . EC:2.3.2.24 (UniProtKB | ENZYME | Rhea)
    • E2 ubiquitin-conjugating enzyme D2
    • Ubiquitin carrier protein D2
    • Ubiquitin-conjugating enzyme E2(17)KB 2
    • Ubiquitin-conjugating enzyme E2-17 kDa 2
    • Ubiquitin-protein ligase D2

Gene names

    • Name
      Ube2d2
    • Synonyms
      Ubc4, Ubch4, Ubch5b

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P62839
  • Secondary accessions
    • P51669

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000824641-147Ubiquitin-conjugating enzyme E2 D2

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in testis.

Interaction

Subunit

Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3. Interacts with PPP1R11.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-147UBC core

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    147
  • Mass (Da)
    16,735
  • Last updated
    2004-08-16 v1
  • Checksum
    C942BE7853CBC355
MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U13176
EMBL· GenBank· DDBJ
AAA85101.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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