ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-159, SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-159, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
data support that Ran GTPase-dependent and independent and moonlighting roles of Ranbp2 or domains thereof and ubc9 control selectively age-dependent neural-type and mitochondrial functions
Depleting TPX2 decreases microtubule formation frequency specifically at the tip and the base of the neurite and these correlate precisely with the regions where active GTP-bound Ran proteins are enriched.
Data suggest Ran activation by RanBP1 in macrophages promotes Legionella phagosome formation and phagocytosis; LegG1 functions as bacterial Ran activator localizes to phagosomes and promotes microtubule stabilization phagocytosis and replication.
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