P62368 · ISPF_PLAF7

Function

function

In the mevalonate-independent isoprenoid biosynthetic pathway, converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site71a divalent metal cation (UniProtKB | ChEBI)
Binding site71-734-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site73a divalent metal cation (UniProtKB | ChEBI)
Site115Transition state stabilizer
Binding site115-1164-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site123a divalent metal cation (UniProtKB | ChEBI)
Binding site137-1394-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site142-1464-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site181-1874-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site212-2144-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Site214Transition state stabilizer

GO annotations

AspectTerm
Cellular Componentapicoplast
Molecular Function2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Molecular Functionmetal ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, apicoplast
  • EC number
  • Short names
    MECDP-synthase
    ; MECPS
  • Alternative names
    • PfIspF

Gene names

    • Name
      IspF
    • ORF names
      PF3D7_0209300, PFB0420w

Organism names

Accessions

  • Primary accession
    P62368
  • Secondary accessions
    • A0A143ZWM3
    • O96178

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, transit peptide.

TypeIDPosition(s)Description
ChainPRO_0000016484?-2402-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, apicoplast
Transit peptide1-?Apicoplast

Proteomic databases

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the IspF family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    240
  • Mass (Da)
    27,161
  • Last updated
    2004-07-05 v1
  • Checksum
    7C46116F48B33D15
MFLKGYTSNVVLIILTFFILLTKEEKNIKNNISGYCFLNFGLKKNAIIKKREKQNLKLFCYNGIRIGQGYDIHKIKVLDEEYNTYANNDFNKNEQSFKTLTLGGVKINNVLVLSHSDGDIIYHSIVDSILGALGSLDIGTLFPDKDEKNKNKNSAIFLRYARLLIYKKNYDIGNVDINVIAQVPKISNIRKNIIKNISTVLNIDESQISVKGKTHEKLGVIGEKKAIECFANILLIPKNS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN999943
EMBL· GenBank· DDBJ
CZT98107.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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