P62334 · PRS10_MOUSE
- Protein26S proteasome regulatory subunit 10B
- GenePsmc6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids389 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosolic proteasome complex | |
Cellular Component | inclusion body | |
Cellular Component | nucleus | |
Cellular Component | proteasome accessory complex | |
Cellular Component | proteasome regulatory particle, base subcomplex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | identical protein binding | |
Molecular Function | proteasome-activating activity | |
Biological Process | ERAD pathway | |
Biological Process | positive regulation of inclusion body assembly | |
Biological Process | positive regulation of RNA polymerase II transcription preinitiation complex assembly | |
Biological Process | proteasome-mediated ubiquitin-dependent protein catabolic process |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name26S proteasome regulatory subunit 10B
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP62334
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000084733 | 1-389 | 26S proteasome regulatory subunit 10B | |||
Sequence: MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV | ||||||
Modified residue | 72 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 206 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 244 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
2D gel databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC6 and few additional components. Interacts with PAAF1.
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length389
- Mass (Da)44,173
- Last updated2004-07-05 v1
- ChecksumB26421295742CACD
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I3BQ49 | A0A2I3BQ49_MOUSE | Psmc6 | 45 | ||
A0A2I3BQ79 | A0A2I3BQ79_MOUSE | Psmc6 | 60 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 144 | in Ref. 1; BAB29293 | ||||
Sequence: E → D | ||||||
Sequence conflict | 222 | in Ref. 1; BAB29293 | ||||
Sequence: A → V | ||||||
Sequence conflict | 241 | in Ref. 2; AAH43044 | ||||
Sequence: R → P | ||||||
Sequence conflict | 281 | in Ref. 1; BAB29293 | ||||
Sequence: R → S |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK012174 EMBL· GenBank· DDBJ | BAB28078.1 EMBL· GenBank· DDBJ | mRNA | ||
AK014354 EMBL· GenBank· DDBJ | BAB29293.1 EMBL· GenBank· DDBJ | mRNA | ||
AK144728 EMBL· GenBank· DDBJ | BAE26034.1 EMBL· GenBank· DDBJ | mRNA | ||
AK166961 EMBL· GenBank· DDBJ | BAE39144.1 EMBL· GenBank· DDBJ | mRNA | ||
BC043044 EMBL· GenBank· DDBJ | AAH43044.1 EMBL· GenBank· DDBJ | mRNA | ||
BC057997 EMBL· GenBank· DDBJ | AAH57997.1 EMBL· GenBank· DDBJ | mRNA |