P62172 · GLNR_BACAN
- ProteinHTH-type transcriptional regulator GlnR
- GeneglnR
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids129 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Transcription repressor during nitrogen excess. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site.
Miscellaneous
The amino acid sequences of the N-terminal DNA binding domains of TnrA and GlnR are highly similar, and both proteins bind to DNA sequences with a common consensus sequence. In contrast, the C-terminal signal transduction domains of TnrA and GlnR have no homology.
Activity regulation
Under conditions of nitrogen excess, the DNA binding activity of GlnR is activated by a transient interaction with feedback-inhibited GlnA. Under conditions of nitrogen-limited, GlnR is autoinhibited by its C-terminal region.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 13-32 | H-T-H motif | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHTH-type transcriptional regulator GlnR
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus > Bacillus cereus group
Accessions
- Primary accessionP62172
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000098119 | 1-129 | HTH-type transcriptional regulator GlnR | ||
Expression
Induction
Under conditions of nitrogen-limited growth, repressed by TnrA.
Interaction
Subunit
Homodimer under conditions of nitrogen excess. Monomer under conditions of nitrogen-limited. Interacts with feedback-inhibited GlnA in order to stabilizes GlnR-DNA complex.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length129
- Mass (Da)15,173
- Last updated2004-06-21 v1
- MD5 Checksum8AA5855DF8F7D507612735144AA915BF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE016879 EMBL· GenBank· DDBJ | AAP27571.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE017334 EMBL· GenBank· DDBJ | AAT32943.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE017225 EMBL· GenBank· DDBJ | AAT55855.1 EMBL· GenBank· DDBJ | Genomic DNA |