P61604 · CH10_HUMAN
- Protein10 kDa heat shock protein, mitochondrial
- GeneHSPE1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids102 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for P61604
Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60.
- AnnotationStructural basis for the structural dynamics of human mitochondrial chaperonin mHsp60.
- CategoriesStructure
- SourceGeneRif: 3336
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
- AnnotationOverexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
- CategoriesExpression
- SourceGeneRif: 3336
Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin.
- Annotationstructural basis for active single- and double-ring complexes coexisting in the mHsp60-mHsp10 chaperonin reaction cycle
- CategoriesStructure
An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space.
- AnnotationAn inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space.
- CategoriesInteraction, Subcellular Location
- SourceGeneRif: 3336
Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
- Annotationelevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma
- CategoriesFunction
- SourceGeneRif: 3336
miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model.
- AnnotationmiR-146a miR-146b and miR-155 are exerting anti-inflammatory properties by down-regulating IL-6 and IL-8 and influencing the expression of HSP10 in the activated endothelium
- CategoriesFunction
- SourceGeneRif: 3336
High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.
- AnnotationHigh expression of HSP10 is negatively associated with estrogen receptor/progesterone receptor status and might be a novel independent biomarker for poor prognosis in invasive ductal breast carcinoma.
- CategoriesExpression
- SourceGeneRif: 3336
Early Pregnancy Factor Enhances the Generation and Function of CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells.
- AnnotationEPF induces the differentiation of regulatory T cells and increases their immunosuppressive activities.
- CategoriesFunction
- SourceGeneRif: 3336
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
- AnnotationHsp10 and Hsp60 may be implicated in carcinogenesis from its very early steps in colorectal cancer.
- CategoriesExpression
- SourceGeneRif: 3336
Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin.
- AnnotationHsp10 has a role in nuclear localization and lung cells response to cigarette smoke
- CategoriesSubcellular Location
- SourceGeneRif: 3336
Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel.
- AnnotationHsp10 and Hsp90 may be involved in large bowel carcinogenesis.
- CategoriesExpression
- SourceGeneRif: 3336
- PubMed
- Europe PMC
- Anticancer Res 34:4153-4159 ()
Mapped toMacromolecular crowding extended to a heptameric system: the Co-chaperonin protein 10.
- AnnotationData show that that in presence of 300 mg/mL Ficoll the thermodynamic stability of each cpn10 monomer increases by over 30% whereas the interfaces are stabilized by less than 10%.
- CategoriesStructure
- SourceGeneRif: 3336
Involvement of HSP10 during the ovarian follicular development of polycystic ovary syndrome: Study in both human ovaries and cultured mouse follicles.
- AnnotationHSP10 protein was detected only in oocytes from human preantral follicles whereas in antral follicles it was localised in oocytes granulosa cells theca cells and stroma cells.
- CategoriesExpression
- SourceGeneRif: 3336
HSP 10 is a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes.
- AnnotationHSP10 was identified as a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes.
- CategoriesSequences
- SourceGeneRif: 3336
Chaperonin 10 as an endothelial-derived differentiation factor: role of glycogen synthase kinase-3.
- AnnotationResults describe a novel function of chaperonin 10 as a general differentiation factor not limited to erythroid cells and show how this biological effect is mediated by GSK-3alpha/beta.
- CategoriesFunction, PTM / Processing
- SourceGeneRif: 3336
Chaperonin chamber accelerates protein folding through passive action of preventing aggregation.
- Annotationthe GroEL-GroES chamber behaves as a passive "Anfinsen cage" whose primary role is to prevent multimolecular association during folding.
- CategoriesFunction
- SourceGeneRif: 3336
Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas.
- AnnotationIn patients with serous ovarian carcinomas gene expression analysis coupled with immunohistochemistry allowed the identification of HSP10 as an independent factor of progression-free survival.
- CategoriesExpression
- SourceGeneRif: 3336
Recombinant EPF/chaperonin 10 promotes the survival of O4-positive pro- oligodendrocytes prepared from neonatal rat brain.
- AnnotationThe effects of cpn 10 on cells of the oligodendrocyte lineage were assessed.
- CategoriesFunction
- SourceGeneRif: 3336
Fibril formation of hsp10 homologue proteins and determination of fibril core regions: differences in fibril core regions dependent on subtle differences in amino acid sequence.
- AnnotationData show that Hhsp10 formed fibrils from only the acidic unfolded state and Core peptide regions of these protein fibrils were determined by proteolysis followed by a combination of Edman degradation and mass spectroscopy analyses.
- CategoriesSequences
- SourceGeneRif: 3336
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
- CategoriesInteraction
- SourceIntAct: P61604
Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma.
- AnnotationAssociated with CANCER: ovarian cancer., Observational study of gene-disease association. (HuGE Navigator)
- CategoriesDisease & Variants, Function, Sequences, Disease & Variants
- SourceGAD:149188, GeneRif: 3336
Heat shock protein 10 and signal transduction: a "capsula eburnea" of carcinogenesis?
- AnnotationIn this review we revise the involvement of Hsp10 in signal transduction pathways and its possible role in cancer etiology.
- CategoriesInteraction, Subcellular Location
- SourceGeneRif: 3336
Single-nucleotide variations in the genes encoding the mitochondrial Hsp60/Hsp10 chaperone system and their disease-causing potential.
- AnnotationInvestigation of single-nucleotide variations in the Hsp10 gene and their disease-causing potential.
- CategoriesSequences
- SourceGeneRif: 3336