P61604 · CH10_HUMAN
- Protein10 kDa heat shock protein, mitochondrial
- GeneHSPE1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids102 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for P61604
Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60.
- AnnotationStructural basis for the structural dynamics of human mitochondrial chaperonin mHsp60.
- CategoriesStructure
- SourceGeneRif: 3336
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
- AnnotationOverexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
- CategoriesExpression
- SourceGeneRif: 3336
Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin.
- Annotationstructural basis for active single- and double-ring complexes coexisting in the mHsp60-mHsp10 chaperonin reaction cycle
- CategoriesStructure
An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space.
- AnnotationAn inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space.
- CategoriesInteraction, Subcellular Location
- SourceGeneRif: 3336
Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.
- AnnotationPathway
- CategoriesFunction
- SourceReactome: R-HSA-9714750
Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
- Annotationelevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma
- CategoriesFunction
- SourceGeneRif: 3336
miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model.
- AnnotationmiR-146a miR-146b and miR-155 are exerting anti-inflammatory properties by down-regulating IL-6 and IL-8 and influencing the expression of HSP10 in the activated endothelium
- CategoriesFunction
- SourceGeneRif: 3336
High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.
- AnnotationHigh expression of HSP10 is negatively associated with estrogen receptor/progesterone receptor status and might be a novel independent biomarker for poor prognosis in invasive ductal breast carcinoma.
- CategoriesExpression
- SourceGeneRif: 3336
Early Pregnancy Factor Enhances the Generation and Function of CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells.
- AnnotationEPF induces the differentiation of regulatory T cells and increases their immunosuppressive activities.
- CategoriesFunction
- SourceGeneRif: 3336
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
- AnnotationHsp10 and Hsp60 may be implicated in carcinogenesis from its very early steps in colorectal cancer.
- CategoriesExpression
- SourceGeneRif: 3336
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
- CategoriesInteraction
- SourceIntAct: P61604
Folding of newly translated membrane protein CCR5 is assisted by the chaperonin GroEL-GroES.
- AnnotationData indicate that on addition of the heat-shock proteins GroEL-GroES molecular chaperone system the folding of the nascent chemokine receptor type 5 (CCR5) was significantly enhanced.
- CategoriesFunction
- SourceGeneRif: 3336
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
- CategoriesInteraction
- SourceIntAct: P61604
Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin.
- AnnotationHsp10 has a role in nuclear localization and lung cells response to cigarette smoke
- CategoriesSubcellular Location
- SourceGeneRif: 3336
Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel.
- AnnotationHsp10 and Hsp90 may be involved in large bowel carcinogenesis.
- CategoriesExpression
- SourceGeneRif: 3336
- PubMed
- Europe PMC
- Anticancer Res 34:4153-4159 ()
Mapped toP-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.
- AnnotationPathway
- CategoriesFunction
- SourceReactome: R-HSA-9714750
Viral immune modulators perturb the human molecular network by common and unique strategies.
- CategoriesInteraction
- SourceIntAct: P61604
Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG.
- AnnotationPathway
- CategoriesFunction
- SourceReactome: R-HSA-9714750
Proteomic analysis of alpha4beta1 integrin adhesion complexes reveals alpha-subunit-dependent protein recruitment.
- CategoriesInteraction
- SourceIntAct: P61604
PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
- CategoriesInteraction
- SourceIntAct: P61604
Toward an understanding of the protein interaction network of the human liver.
- CategoriesInteraction
- SourceIntAct: P61604
Macromolecular crowding extended to a heptameric system: the Co-chaperonin protein 10.
- AnnotationData show that that in presence of 300 mg/mL Ficoll the thermodynamic stability of each cpn10 monomer increases by over 30% whereas the interfaces are stabilized by less than 10%.
- CategoriesStructure
- SourceGeneRif: 3336