P61599 · NAA20_HUMAN

  • Protein
    N-alpha-acetyltransferase 20
  • Gene
    NAA20
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638).
Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular ComponentNatB complex
Cellular Componentnucleus
Molecular Functionpeptide alpha-N-acetyltransferase activity
Biological ProcessN-terminal peptidyl-aspartic acid acetylation
Biological ProcessN-terminal peptidyl-glutamic acid acetylation
Biological ProcessN-terminal peptidyl-glutamine acetylation
Biological ProcessN-terminal protein amino acid acetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-alpha-acetyltransferase 20
  • EC number
  • Alternative names
    • Methionine N-acetyltransferase
    • N-acetyltransferase 5
    • N-terminal acetyltransferase B complex catalytic subunit NAA20
    • N-terminal acetyltransferase B complex catalytic subunit NAT5 (NatB complex subunit NAT5)
    • NatB catalytic subunit

Gene names

    • Name
      NAA20
    • Synonyms
      NAT5

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P61599
  • Secondary accessions
    • A6NHA3
    • B2R4G4
    • Q5TFT7
    • Q9D7H8
    • Q9H0Y4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Involvement in disease

Intellectual developmental disorder, autosomal recessive 73 (MRT73)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT73 patients manifest global developmental delay with hypotonia and mildly delayed walking, impaired intellectual development with poor or absent speech, and mildly dysmorphic features.
  • See also
    MIM:619717
Natural variants in MRT73
Variant IDPosition(s)ChangeDescription
VAR_0884254L>Pin MRT73; decreases interaction with NAA25; may reduce protein capacity to acetylate Met-Glu N-terminal peptides; does not affect protein stability; dbSNP:rs752372862
VAR_08842634-178missingin MRT73; dbSNP:rs755734957
VAR_08680954M>Vin MRT73; decreased complex formation with NAA25 and decreased N-acetylation catalytic activity in vitro for all 4 types of substrates; does not affect protein stability; dbSNP:rs2146464332
VAR_08681080A>Vin MRT73; strong decrease in N-acetylation catalytic activity in vitro for substrates Met-Glu, Met-Asn and Met-Gln, but not Met-Asp; does not affect protein stability; dbSNP:rs768029717

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_0884254in MRT73; decreases interaction with NAA25; may reduce protein capacity to acetylate Met-Glu N-terminal peptides; does not affect protein stability; dbSNP:rs752372862
Natural variantVAR_08842634-178in MRT73; dbSNP:rs755734957
Natural variantVAR_08680954in MRT73; decreased complex formation with NAA25 and decreased N-acetylation catalytic activity in vitro for all 4 types of substrates; does not affect protein stability; dbSNP:rs2146464332
Natural variantVAR_08681080in MRT73; strong decrease in N-acetylation catalytic activity in vitro for substrates Met-Glu, Met-Asn and Met-Gln, but not Met-Asp; does not affect protein stability; dbSNP:rs768029717

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 171 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000745341-178N-alpha-acetyltransferase 20

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P61599NAA25 Q14CX72EBI-1055023, EBI-1048503
View interactors in UniProtKB
View CPX-6270 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-157N-acetyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P61599-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    178
  • Mass (Da)
    20,368
  • Last updated
    2004-05-24 v1
  • Checksum
    C5CCEA50CD60E097
MTTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE

P61599-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 103-178: KGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE → YEESTFQGY

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A8MZB2A8MZB2_HUMANNAA20166

Sequence caution

The sequence BG548527 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict47in Ref. 2; CAB66576
Alternative sequenceVSP_045644103-178in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF085355
EMBL· GenBank· DDBJ
AAD40190.1
EMBL· GenBank· DDBJ
mRNA
AL136641
EMBL· GenBank· DDBJ
CAB66576.1
EMBL· GenBank· DDBJ
mRNA
AK311819
EMBL· GenBank· DDBJ
BAG34761.1
EMBL· GenBank· DDBJ
mRNA
AL049538
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL035454
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471133
EMBL· GenBank· DDBJ
EAX10214.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471133
EMBL· GenBank· DDBJ
EAX10215.1
EMBL· GenBank· DDBJ
Genomic DNA
BC005181
EMBL· GenBank· DDBJ
AAH05181.1
EMBL· GenBank· DDBJ
mRNA
BC008446
EMBL· GenBank· DDBJ
AAH08446.1
EMBL· GenBank· DDBJ
mRNA
BG548527
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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