P61254 · RL26_HUMAN

  • Protein
    Large ribosomal subunit protein uL24
  • Gene
    RPL26
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the large ribosomal subunit (PubMed:23636399, PubMed:26100019, PubMed:32669547).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:26100019, PubMed:32669547).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentcytosolic large ribosomal subunit
Cellular Componentcytosolic ribosome
Cellular Componentextracellular exosome
Cellular Componentmembrane
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentribonucleoprotein complex
Cellular Componentsynapse
Molecular FunctionmRNA 5'-UTR binding
Molecular FunctionRNA binding
Molecular Functionstructural constituent of ribosome
Biological Processcellular response to gamma radiation
Biological Processcellular response to UV
Biological Processcytoplasmic translation
Biological ProcessDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Biological Processpositive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Biological Processpositive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Processpositive regulation of translation
Biological Processregulation of translation involved in cellular response to UV
Biological Processribosomal large subunit biogenesis
Biological ProcessrRNA processing
Biological Processtranslation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Large ribosomal subunit protein uL24
  • Alternative names
    • 60S ribosomal protein L26

Gene names

    • Name
      RPL26

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P61254
  • Secondary accessions
    • B2R4F0
    • D3DTR8
    • Q02877
    • Q6IPY2

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Diamond-Blackfan anemia 11 (DBA11)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
  • See also
    MIM:614900

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 138 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), cross-link, modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00001307871-145UniProtLarge ribosomal subunit protein uL24
Modified residue (large scale data)9PRIDEPhosphoserine
Modified residue (large scale data)12PRIDEPhosphoserine
Modified residue (large scale data)23PRIDEPhosphoserine
Modified residue (large scale data)32PRIDEPhosphoserine
Cross-link136UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue139UniProtPhosphothreonine
Modified residue (large scale data)139PRIDEPhosphothreonine

Post-translational modification

Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the large ribosomal subunit (PubMed:23636399, PubMed:26100019, PubMed:32669547).
Interacts with DHX33 (PubMed:26100019).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-21Disordered
Region122-145Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    145
  • Mass (Da)
    17,258
  • Last updated
    2004-05-10 v1
  • Checksum
    049D53AB4E3F46B6
MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEETIEKMQE

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
J3KS10J3KS10_HUMANRPL2663
J3KSS0J3KSS0_HUMANRPL2663
J3QQV1J3QQV1_HUMANRPL26110
J3QRI7J3QRI7_HUMANRPL26107
J3QRC4J3QRC4_HUMANRPL26135

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict133in Ref. 2; AAA60279

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X69392
EMBL· GenBank· DDBJ
CAA49189.1
EMBL· GenBank· DDBJ
mRNA
L07287
EMBL· GenBank· DDBJ
AAA60279.1
EMBL· GenBank· DDBJ
Genomic DNA
AB061829
EMBL· GenBank· DDBJ
BAB79467.1
EMBL· GenBank· DDBJ
Genomic DNA
AK311804
EMBL· GenBank· DDBJ
BAG34747.1
EMBL· GenBank· DDBJ
mRNA
CH471108
EMBL· GenBank· DDBJ
EAW90053.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471108
EMBL· GenBank· DDBJ
EAW90054.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471108
EMBL· GenBank· DDBJ
EAW90057.1
EMBL· GenBank· DDBJ
Genomic DNA
BC071664
EMBL· GenBank· DDBJ
AAH71664.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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