P60892 · PRPS1_RAT
- ProteinRibose-phosphate pyrophosphokinase 1
- GenePrps1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids318 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Catalytic activity
- ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H+
Cofactor
Activity regulation
Activated by magnesium and inorganic phosphate.
Pathway
Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 96-101 | ATP (UniProtKB | ChEBI) | ||||
Sequence: RQDKKD | ||||||
Binding site | 128 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 130 | ATP (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 130 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 139 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 143 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | protein-containing complex | |
Cellular Component | ribose phosphate diphosphokinase complex | |
Molecular Function | ADP binding | |
Molecular Function | AMP binding | |
Molecular Function | ATP binding | |
Molecular Function | carbohydrate binding | |
Molecular Function | GDP binding | |
Molecular Function | identical protein binding | |
Molecular Function | kinase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | ribose phosphate diphosphokinase activity | |
Biological Process | 5-phosphoribose 1-diphosphate biosynthetic process | |
Biological Process | AMP biosynthetic process | |
Biological Process | animal organ regeneration | |
Biological Process | hypoxanthine biosynthetic process | |
Biological Process | nervous system development | |
Biological Process | pentose-phosphate shunt | |
Biological Process | purine nucleobase metabolic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | urate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibose-phosphate pyrophosphokinase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP60892
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000141073 | 1-318 | Ribose-phosphate pyrophosphokinase 1 | |||
Sequence: MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 212-227 | Binding of phosphoribosylpyrophosphate | ||||
Sequence: KDRVAILVDDMADTCG |
Sequence similarities
Belongs to the ribose-phosphate pyrophosphokinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length318
- Mass (Da)34,834
- Last updated2007-01-23 v2
- Checksum46D017E969908BA0
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 163 | in Ref. 4; AAH88149 | ||||
Sequence: R → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M17258 EMBL· GenBank· DDBJ | AAA41963.1 EMBL· GenBank· DDBJ | mRNA | ||
M29392 EMBL· GenBank· DDBJ | AAA41960.1 EMBL· GenBank· DDBJ | mRNA | ||
X16554 EMBL· GenBank· DDBJ | CAA34555.1 EMBL· GenBank· DDBJ | mRNA | ||
M31084 EMBL· GenBank· DDBJ | AAA41959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M31078 EMBL· GenBank· DDBJ | AAA41959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M31079 EMBL· GenBank· DDBJ | AAA41959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M31080 EMBL· GenBank· DDBJ | AAA41959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M31082 EMBL· GenBank· DDBJ | AAA41959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M31083 EMBL· GenBank· DDBJ | AAA41959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC078853 EMBL· GenBank· DDBJ | AAH78853.1 EMBL· GenBank· DDBJ | mRNA | ||
BC088149 EMBL· GenBank· DDBJ | AAH88149.1 EMBL· GenBank· DDBJ | mRNA |