P60857 · PTGA_STAAN

Function

function

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization.

Features

Showing features for binding site, site, active site.

116620406080100120140160
Type
IDPosition(s)Description
Binding site71Zn2+ (UniProtKB | ChEBI); ligand shared with glycerol kinase
Site71Important for phospho-donor activity
Active site86Tele-phosphohistidine intermediate; for EIIA activity
Binding site86Zn2+ (UniProtKB | ChEBI); ligand shared with glycerol kinase

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionkinase activity
Molecular Functionmetal ion binding
Biological Processphosphoenolpyruvate-dependent sugar phosphotransferase system

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    PTS system glucose-specific EIIA component
  • Alternative names
    • EIIA-Glc
    • EIII-Glc
    • Glucose-specific phosphotransferase enzyme IIA component

Gene names

    • Name
      crr
    • Ordered locus names
      SA1255

Organism names

Accessions

  • Primary accession
    P60857
  • Secondary accessions
    • Q99U65

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001865491-166PTS system glucose-specific EIIA component
Modified residue86Phosphohistidine; by HPr

Keywords

Interaction

Subunit

Heterodimer with glycerol kinase (glpk).

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain34-138PTS EIIA type-1

Domain

The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    166
  • Mass (Da)
    17,961
  • Last updated
    2004-04-13 v1
  • MD5 Checksum
    C386273F95F50C9CD1EC65B69A2EAED6
MFKKLFGKGKEVQKDIAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLDGEGFEVLVSSGDEVNVGDPLVRFNLEFINNNAKSVISPIIITNTDQAASINIYDENAVIKGETKVIDVTMN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000018
EMBL· GenBank· DDBJ
BAB42515.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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