P60857 · PTGA_STAAN
- ProteinPTS system glucose-specific EIIA component
- Genecrr
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids166 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport.
Cofactor
Note: Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 71 | Zn2+ (UniProtKB | ChEBI); ligand shared with glycerol kinase | |||
Site | 71 | Important for phospho-donor activity | |||
Active site | 86 | Tele-phosphohistidine intermediate; for EIIA activity | |||
Binding site | 86 | Zn2+ (UniProtKB | ChEBI); ligand shared with glycerol kinase | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | kinase activity | |
Molecular Function | metal ion binding | |
Biological Process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended namePTS system glucose-specific EIIA component
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillati > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionP60857
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000186549 | 1-166 | PTS system glucose-specific EIIA component | ||
Modified residue | 86 | Phosphohistidine; by HPr | |||
Keywords
- PTM
Interaction
Subunit
Heterodimer with glycerol kinase (glpk).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 34-138 | PTS EIIA type-1 | |||
Domain
The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length166
- Mass (Da)17,961
- Last updated2004-04-13 v1
- MD5 ChecksumC386273F95F50C9CD1EC65B69A2EAED6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000018 EMBL· GenBank· DDBJ | BAB42515.1 EMBL· GenBank· DDBJ | Genomic DNA |