P60790 · LEPA_LACJO

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Catalytic activity

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site23-28GTP (UniProtKB | ChEBI)
Binding site140-143GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • Ordered locus names
      LJ_1477

Organism names

Accessions

  • Primary accession
    P60790

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001762841-612Elongation factor 4

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-193tr-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    612
  • Mass (Da)
    68,888
  • Last updated
    2004-04-13 v1
  • Checksum
    E83145408B315368
MDIKKLQDYQKHIRNFSIVAHIDHGKSTIADRILELTDTVSERQMKNQLLDDMPLERQRGITIKLNSVEVKYHAKDGETYIFHLIDTPGHVDFSYEVSRSLAACEGALLVVDATQGVQAQTLANTYLAIDDDLEILPVINKIDLPSADPEMCKNEIEEMIGLDASDAVEVSGKTGQGIPELLEEIVKKVPAPDGDLNAPLKALIFDSKYDDYRGVVLSVRIEEGTVKPGDKIRIMNTGKEFEVTEVGVSSPHPVKKDMLIAGDVGYLTANIKSVRETRVGDTITSAETPTEKPLPGYRQIPPMVYSGMYPVDNQKYDDLKEALQKLQLNDAALEFEPETSQALGFGFRCGFLGLLHMDVVQERLEQEFGMDLIMTAPSVDYHAIMNDGSTKLIDNPADLPDAGEYKEVQEPYVKAEIMVPNDFVGPVMELCQRKRGEFVTMDYLDKYRVNVIYNMPLAEIIYDFFDELKSSTKGYASLDYEITGYRATDLVKIDMLLNKEPIDALSFIAHREEAQNRARQMTTMLKKLIPRQNFEVDIQGAIGAKIISRATIKPYRKDVTWKIHTGDPDRRAKLLEKQRRGKKRMKAVGRVEVPQDAFMAVLKMNDDDIKGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017198
EMBL· GenBank· DDBJ
AAS09245.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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