P60690 · MNHE1_STAAU

  • Protein
    Na(+)/H(+) antiporter subunit E1
  • Gene
    mnhE1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Mnh complex is a Na+Li+/H+ antiporter involved in Na+ and/or Li+ excretion. Na+/H+ antiport consumes a transmembrane electrical potential, and is thus inferred to be electrogenic. Does not transport K+, Ca2+ or Mg2+.

Activity regulation

Na+ extrusion is completely inhibited by the H+ conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionantiporter activity
Molecular Functionmonoatomic cation transmembrane transporter activity
Biological Processproton transmembrane transport
Biological Processsodium ion transport

Keywords

Protein family/group databases

    • 2.A.63.1.3the monovalent cation (k+ or na+):proton antiporter-3 (cpa3) family

Names & Taxonomy

Protein names

  • Recommended name
    Na(+)/H(+) antiporter subunit E1
  • Alternative names
    • Mnh complex subunit E1
    • Mrp complex subunit E1

Gene names

    • Name
      mnhE1
    • Synonyms
      mrpE1

Organism names

  • Taxonomic identifier
  • Strains
    • ATCC 21027 / 209-P
    • RF4220
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    P60690
  • Secondary accessions
    • Q0Q2K3
    • Q9ZNG2

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane5-22Helical
Transmembrane27-45Helical
Transmembrane52-69Helical
Transmembrane100-122Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002170911-159Na+/H+ antiporter subunit E1

Interaction

Subunit

May form a heterooligomeric complex that consists of seven subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    159
  • Mass (Da)
    18,319
  • Last updated
    2004-04-13 v1
  • Checksum
    95C11B67E678D3B7
MAVQLVLNFIIAVFWLFVTNSYTTNNFVLGFIFGLVLVYLLHRVLPGRFYVITLYRIIKLVIIFLIELIKANFDVLKIIIKPSIKNEPGFFVYHTDLKKDWQIVLLSNLITLTPGTVVLGVSDDRTKIYIHAIDFSTKEQEVESIKTSLEKIVREVGEI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB015981
EMBL· GenBank· DDBJ
BAA35099.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ659238
EMBL· GenBank· DDBJ
ABG67114.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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