P60468 · SC61B_HUMAN

  • Protein
    Protein transport protein Sec61 subunit beta
  • Gene
    SEC61B
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939).
Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939).
The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522).
The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentendoplasmic reticulum quality control compartment
Cellular Componentendoplasmic reticulum Sec complex
Cellular Componentmembrane
Cellular ComponentSec61 translocon complex
Molecular Functionepidermal growth factor binding
Molecular Functionguanyl-nucleotide exchange factor activity
Molecular Functionribosome binding
Molecular FunctionRNA binding
Biological ProcessERAD pathway
Biological Processpost-translational protein targeting to membrane, translocation
Biological Processretrograde protein transport, ER to cytosol
Biological ProcessSRP-dependent cotranslational protein targeting to membrane, translocation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein transport protein Sec61 subunit beta

Gene names

    • Name
      SEC61B

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P60468
  • Secondary accessions
    • P38390
    • P38391
    • Q6IBC1

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain2-70Cytoplasmic
Transmembrane71-91Helical
Topological domain92-96Lumenal

Keywords

Disease & Variants

Involvement in disease

  • Loss-of-function SEC61B variations may cause autosomal dominant polycystic liver disease (PCLD) in patients that lack variations in known causative genes, such as PRKCSH and SEC63

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis39Abolishes S-acylation.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 106 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, modified residue (large scale data), lipidation.

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtRemoved
Modified residue2UniProtN-acetylproline
ChainPRO_00001572542-96UniProtProtein transport protein Sec61 subunit beta
Modified residue (large scale data)5PRIDEPhosphothreonine
Modified residue7UniProtPhosphoserine
Modified residue (large scale data)7PRIDEPhosphoserine
Modified residue9UniProtPhosphothreonine
Modified residue (large scale data)9PRIDEPhosphothreonine
Modified residue13UniProtPhosphoserine
Modified residue (large scale data)13PRIDEPhosphoserine
Modified residue14UniProtPhosphoserine
Modified residue (large scale data)14PRIDEPhosphoserine
Modified residue17UniProtPhosphoserine
Modified residue (large scale data)17PRIDEPhosphoserine
Modified residue (large scale data)19PRIDEPhosphoserine
Lipidation39UniProtS-palmitoyl cysteine
Modified residue (large scale data)49PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity).
The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522).
Interacts with TRAM1 (PubMed:19121997).

Binary interactions

View interactors in UniProtKB
View CPX-8073 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Region1-54Disordered
Compositional bias31-54Polar residues

Sequence similarities

Belongs to the SEC61-beta family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    96
  • Mass (Da)
    9,974
  • Last updated
    2007-01-23 v2
  • Checksum
    5FAFF4197A62FA49
MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
S4R3B5S4R3B5_HUMANSEC61B42

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Compositional bias31-54Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L25085
EMBL· GenBank· DDBJ
AAA19706.1
EMBL· GenBank· DDBJ
mRNA
CR456883
EMBL· GenBank· DDBJ
CAG33164.1
EMBL· GenBank· DDBJ
mRNA
AL137067
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC001734
EMBL· GenBank· DDBJ
AAH01734.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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