P60168 · V_MEASY

Function

function

Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Moderately affects the type II interferon signaling (By similarity).

Features

Showing features for binding site, site.

129920406080100120140160180200220240260280
Type
IDPosition(s)Description
Binding site232Zn2+ 1 (UniProtKB | ChEBI)
Site240Interaction with host STAT2
Site246Interaction with host STAT2
Site248Interaction with host STAT2
Site250Interaction with host STAT2
Binding site251Zn2+ 1 (UniProtKB | ChEBI)
Binding site255Zn2+ 2 (UniProtKB | ChEBI)
Binding site267Zn2+ 2 (UniProtKB | ChEBI)
Binding site269Zn2+ 2 (UniProtKB | ChEBI)
Binding site272Zn2+ 2 (UniProtKB | ChEBI)
Binding site276Zn2+ 1 (UniProtKB | ChEBI)
Binding site279Zn2+ 1 (UniProtKB | ChEBI)

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Non-structural protein V

Gene names

    • Name
      P/V

Organism names

Accessions

  • Primary accession
    P60168

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001428121-299Non-structural protein V

Interaction

Subunit

Interacts with host IFIH1/MDA5 and DHX58/LGP2; these interactions are involved in the inhibition of the host type I interferon signaling pathway. Interacts with host TYK2; this interaction inhibits the type I interferon signaling pathway without affecting the type II pathway. Interacts with host IRF7; this interaction inhibits IRF7 translocation to the nucleus. Interacts with host CHUK (By similarity).
Interacts with host RELA/p65; this interaction inhibits the nuclear translocation of NF-KappaB (By similarity).
Interacts (via N-terminus) with host STAT1 and JAK1; these interactions inhibit STAT1 phosphorylation by Jak1 and thereby the type I interferon signaling pathway. Interacts (via C-terminus) with host STAT2; this interaction is involved in the inhibition of the host type I interferon signaling pathway. Forms a complex with host PPP1CA and PPP1CC; this interaction prevents dephosphorylation of host IFIH1/MDA5 and leads to the inhibition of the host type I interferon signaling pathway. Interacts with host IRF9; this interaction prevents the binding of IRF9 to STAT2 and thereby the type I interferon signaling pathway (By similarity).

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region40-91Disordered
Region110-120Interaction with host STAT1
Region133-163Disordered
Compositional bias142-156Acidic residues

Domain

The N-terminus interacts with host JAK1 and STAT1 (By similarity).
The C-terminus interacts with host STAT2 (By similarity).
The C-terminus also interacts with host PP1 (By similarity).

Sequence similarities

Belongs to the paramyxoviruses V protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    299
  • Mass (Da)
    32,132
  • Last updated
    2003-12-15 v1
  • Checksum
    BB3913613CB6BD3A
MAEEQARHVKNGLECIRALKAEPIGSLAIGEAMAAWSEISDNPGQERATYKEEKAGGSGLSKPCLSAIGSTEGGAPRIRGQGSGESDDDTETLGIPSRNLQASSTGLQCHYVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSEGDNESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGGEIHELLRLQSRGNNFPKLGKTLNVPPPPDPGRASTSETPIKKGHRREISLIWDGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVCEQCRTDTGVDTRIWYHNLPEIPE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias142-156Acidic residues

RNA Editing

Edited at position 231
Partially edited. RNA editing at this position consists of an insertion of one guanine nucleotide. The sequence displayed here is the V protein, derived from the edited RNA. The unedited RNA gives rise to the P protein (AC Q00793)

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D10635
EMBL· GenBank· DDBJ
-mRNA No translation available.

Similar Proteins

Disclaimer

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