P60168 · V_MEASY
- ProteinNon-structural protein V
- GeneP/V
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids299 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Moderately affects the type II interferon signaling (By similarity).
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 232 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Site | 240 | Interaction with host STAT2 | |||
Site | 246 | Interaction with host STAT2 | |||
Site | 248 | Interaction with host STAT2 | |||
Site | 250 | Interaction with host STAT2 | |||
Binding site | 251 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 255 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 267 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 269 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 272 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 276 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 279 | Zn2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasm | |
Molecular Function | metal ion binding | |
Biological Process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity | |
Biological Process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity | |
Biological Process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity | |
Biological Process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNon-structural protein V
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Paramyxoviridae > Orthoparamyxovirinae > Morbillivirus > Morbillivirus hominis > Measles morbillivirus
- Virus hosts
Accessions
- Primary accessionP60168
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000142812 | 1-299 | Non-structural protein V | ||
Interaction
Subunit
Interacts with host IFIH1/MDA5 and DHX58/LGP2; these interactions are involved in the inhibition of the host type I interferon signaling pathway. Interacts with host TYK2; this interaction inhibits the type I interferon signaling pathway without affecting the type II pathway. Interacts with host IRF7; this interaction inhibits IRF7 translocation to the nucleus. Interacts with host CHUK (By similarity).
Interacts with host RELA/p65; this interaction inhibits the nuclear translocation of NF-KappaB (By similarity).
Interacts (via N-terminus) with host STAT1 and JAK1; these interactions inhibit STAT1 phosphorylation by Jak1 and thereby the type I interferon signaling pathway. Interacts (via C-terminus) with host STAT2; this interaction is involved in the inhibition of the host type I interferon signaling pathway. Forms a complex with host PPP1CA and PPP1CC; this interaction prevents dephosphorylation of host IFIH1/MDA5 and leads to the inhibition of the host type I interferon signaling pathway. Interacts with host IRF9; this interaction prevents the binding of IRF9 to STAT2 and thereby the type I interferon signaling pathway (By similarity).
Interacts with host RELA/p65; this interaction inhibits the nuclear translocation of NF-KappaB (By similarity).
Interacts (via N-terminus) with host STAT1 and JAK1; these interactions inhibit STAT1 phosphorylation by Jak1 and thereby the type I interferon signaling pathway. Interacts (via C-terminus) with host STAT2; this interaction is involved in the inhibition of the host type I interferon signaling pathway. Forms a complex with host PPP1CA and PPP1CC; this interaction prevents dephosphorylation of host IFIH1/MDA5 and leads to the inhibition of the host type I interferon signaling pathway. Interacts with host IRF9; this interaction prevents the binding of IRF9 to STAT2 and thereby the type I interferon signaling pathway (By similarity).
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 40-91 | Disordered | |||
Region | 110-120 | Interaction with host STAT1 | |||
Region | 133-163 | Disordered | |||
Compositional bias | 142-156 | Acidic residues | |||
Domain
The N-terminus interacts with host JAK1 and STAT1 (By similarity).
The C-terminus interacts with host STAT2 (By similarity).
The C-terminus also interacts with host PP1 (By similarity).
The C-terminus interacts with host STAT2 (By similarity).
The C-terminus also interacts with host PP1 (By similarity).
Sequence similarities
Belongs to the paramyxoviruses V protein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)32,132
- Last updated2003-12-15 v1
- ChecksumBB3913613CB6BD3A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 142-156 | Acidic residues | |||
RNA Editing
Edited at position 231
Partially edited. RNA editing at this position consists of an insertion of one guanine nucleotide. The sequence displayed here is the V protein, derived from the edited RNA. The unedited RNA gives rise to the P protein (AC Q00793)
Keywords
- Coding sequence diversity
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D10635 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |