P60153 · RNAS9_HUMAN

  • Protein
    Inactive ribonuclease-like protein 9
  • Gene
    RNASE9
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Does not exhibit any ribonuclease activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionnucleic acid binding
Biological Processdefense response to Gram-positive bacterium

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inactive ribonuclease-like protein 9

Gene names

    • Name
      RNASE9

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P60153
  • Secondary accessions
    • A2RQR8
    • A8QJS1
    • Q5GAN7
    • Q6KG53

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_052197148in dbSNP:rs12590446
Natural variantVAR_034473204in dbSNP:rs1243647

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 319 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000003095127-205Inactive ribonuclease-like protein 9
Disulfide bond116↔168
Disulfide bond123↔130
Glycosylation131N-linked (GlcNAc...) asparagine
Glycosylation143N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

At the mRNA level, widely expressed (PubMed:18992174).
At protein level, restricted to epididymis (PubMed:19137000).
Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymal sperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (at protein level). Not detected in muscle

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

P60153-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    alpha1, alpha2, alpha12, beta2, beta12
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    205
  • Mass (Da)
    24,307
  • Last updated
    2003-11-28 v1
  • Checksum
    EDE63F0727282BF6
MMRTLITTHPLPLLLLPQQLLQLVQFQEVDTDFDFPEEDKKEEFEECLEKFFSTGPARPPTKEKVKRRVLIEPGMPLNHIEYCNHEIMGKNVYYKHRWVAEHYFLLMQYDELQKICYNRFVPCKNGIRKCNRSKGLVEGVYCNLTEAFEIPACKYESLYRKGYVLITCSWQNEMQKRIPHTINDLVEPPEHRSFLSEDGVFVISP

P60153-2

  • Name
    2
  • Synonyms
    alpha23, alpha123
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-1: M → MSAGKM

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAG2RNW0A0AAG2RNW0_HUMANRNASE9204

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0418561in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY665804
EMBL· GenBank· DDBJ
AAV87182.1
EMBL· GenBank· DDBJ
mRNA
EU414264
EMBL· GenBank· DDBJ
ACA49544.1
EMBL· GenBank· DDBJ
mRNA
AF382949
EMBL· GenBank· DDBJ
AAQ02792.1
EMBL· GenBank· DDBJ
mRNA
AY907670
EMBL· GenBank· DDBJ
AAX86045.1
EMBL· GenBank· DDBJ
mRNA
EF061296
EMBL· GenBank· DDBJ
ABP97451.1
EMBL· GenBank· DDBJ
mRNA
EF061297
EMBL· GenBank· DDBJ
ABP97452.1
EMBL· GenBank· DDBJ
mRNA
EF061298
EMBL· GenBank· DDBJ
ABP97453.1
EMBL· GenBank· DDBJ
mRNA
EF061299
EMBL· GenBank· DDBJ
ABP97454.1
EMBL· GenBank· DDBJ
mRNA
EF061300
EMBL· GenBank· DDBJ
ABP97455.1
EMBL· GenBank· DDBJ
mRNA
EF061301
EMBL· GenBank· DDBJ
ABP97456.1
EMBL· GenBank· DDBJ
mRNA
EF061302
EMBL· GenBank· DDBJ
ABP97457.1
EMBL· GenBank· DDBJ
mRNA
EF061303
EMBL· GenBank· DDBJ
ABP97458.1
EMBL· GenBank· DDBJ
mRNA
EF061304
EMBL· GenBank· DDBJ
ABP97459.1
EMBL· GenBank· DDBJ
mRNA
AL163195
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC130311
EMBL· GenBank· DDBJ
AAI30312.1
EMBL· GenBank· DDBJ
mRNA
BC130313
EMBL· GenBank· DDBJ
AAI30314.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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