The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueLimbCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase.Liszt G., Ford E., Kurtev M., Guarente L.View abstractCited forCATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, ACTIVE SITE, MUTAGENESIS OF SER-56 AND HIS-133CategoriesFunction, Expression, Phenotypes & Variants, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 280:21313-21320 (2005)Cited in1Mapped to2
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.Mostoslavsky R., Chua K.F., Lombard D.B., Pang W.W., Fischer M.R., Gellon L., Liu P., Mostoslavsky G., Franco S.[...], Alt F.W.View abstractCited forDISRUPTION PHENOTYPE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITYCategoriesFunction, Expression, Phenotypes & Variants, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 124:315-329 (2006)Cited in1Mapped to2
Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD.Du J., Jiang H., Lin H.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochemistry 48:2878-2890 (2009)Cited in4Mapped to7
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.Kawahara T.L.A., Michishita E., Adler A.S., Damian M., Berber E., Lin M., McCord R.A., Ongaigui K.C.L., Boxer L.D.[...], Chua K.F.View abstractCited forFUNCTION, INTERACTION WITH RELACategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 136:62-74 (2009)Cited in2Mapped to15
The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability.Yang B., Zwaans B.M.M., Eckersdorff M., Lombard D.B.Cited forFUNCTION, ACTIVE SITE, MUTAGENESIS OF HIS-133CategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Cycle 8:2662-2663 (2009)Cited in1
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.Van Gool F., Galli M., Gueydan C., Kruys V., Prevot P.P., Bedalov A., Mostoslavsky R., Alt F.W., De Smedt T., Leo O.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Med. 15:206-210 (2009)Cited in1Mapped to15
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.Zhong L., D'Urso A., Toiber D., Sebastian C., Henry R.E., Vadysirisack D.D., Guimaraes A., Marinelli B., Wikstrom J.D.[...], Mostoslavsky R.View abstractCited forFUNCTION IN REGULATION OF GLUCOSE HOMEOSTASISCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 140:280-293 (2010)Cited in1Mapped to7
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.Kim H.S., Xiao C., Wang R.H., Lahusen T., Xu X., Vassilopoulos A., Vazquez-Ortiz G., Jeong W.I., Park O.[...], Deng C.X.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Metab. 12:224-236 (2010)Cited in1Mapped to13
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.Xiao C., Kim H.S., Lahusen T., Wang R.H., Xu X., Gavrilova O., Jou W., Gius D., Deng C.X.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 285:36776-36784 (2010)Cited in1Mapped to17
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.Schwer B., Schumacher B., Lombard D.B., Xiao C., Kurtev M.V., Gao J., Schneider J.I., Chai H., Bronson R.T.[...], Alt F.W.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 107:21790-21794 (2010)Cited in1Mapped to2
SIRT6 promotes DNA repair under stress by activating PARP1.Mao Z., Hine C., Tian X., Van Meter M., Au M., Vaidya A., Seluanov A., Gorbunova V.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 332:1443-1446 (2011)Cited in4Mapped to24
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.Sebastian C., Zwaans B.M., Silberman D.M., Gymrek M., Goren A., Zhong L., Ram O., Truelove J., Guimaraes A.R.[...], Mostoslavsky R.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 151:1185-1199 (2012)Cited in2Mapped to23
The sirtuin SIRT6 regulates lifespan in male mice.Kanfi Y., Naiman S., Amir G., Peshti V., Zinman G., Nahum L., Bar-Joseph Z., Cohen H.Y.View abstractCited forFUNCTION IN REGULATION OF LIFE SPANCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 483:218-221 (2012)Cited in1Mapped to2
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.Dominy J.E. Jr., Lee Y., Jedrychowski M.P., Chim H., Jurczak M.J., Camporez J.P., Ruan H.B., Feldman J., Pierce K.[...], Puigserver P.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell 48:900-913 (2012)Cited in6Mapped to23
FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression.Tao R., Xiong X., DePinho R.A., Deng C.X., Dong X.C.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 288:29252-29259 (2013)Cited in1Mapped to25
SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.Toiber D., Erdel F., Bouazoune K., Silberman D.M., Zhong L., Mulligan P., Sebastian C., Cosentino C., Martinez-Pastor B.[...], Mostoslavsky R.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell 51:454-468 (2013)Cited in3Mapped to2
SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine.Jiang H., Khan S., Wang Y., Charron G., He B., Sebastian C., Du J., Kim R., Ge E.[...], Lin H.View abstractCited forSUBCELLULAR LOCATIONCategoriesSubcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 496:110-113 (2013)Cited in3Mapped to24
Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.Masri S., Rigor P., Cervantes M., Ceglia N., Sebastian C., Xiao C., Roqueta-Rivera M., Deng C., Osborne T.F.[...], Sassone-Corsi P.View abstractCited forFUNCTION, INTERACTION WITH THE CLOCK-BMAL1 COMPLEXCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 158:659-672 (2014)Cited in1Mapped to15
SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.Van Meter M., Kashyap M., Rezazadeh S., Geneva A.J., Morello T.D., Seluanov A., Gorbunova V.View abstractCited forFUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF SER-56; GLY-60 AND ARG-65CategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Commun. 5:5011-5011 (2014)Cited in2Mapped to2
Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.Zhang P., Tu B., Wang H., Cao Z., Tang M., Zhang C., Gu B., Li Z., Wang L.[...], Zhu W.G.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 111:10684-10689 (2014)Cited in4Mapped to99+
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET- mediated production of 5-hydroxymethylcytosine.Etchegaray J.P., Chavez L., Huang Y., Ross K.N., Choi J., Martinez-Pastor B., Walsh R.M., Sommer C.A., Lienhard M.[...], Mostoslavsky R.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Cell Biol. 17:545-557 (2015)Cited in2Mapped to19
SIRT6 suppresses pancreatic cancer through control of Lin28b.Kugel S., Sebastian C., Fitamant J., Ross K.N., Saha S.K., Jain E., Gladden A., Arora K.S., Kato Y.[...], Mostoslavsky R.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 165:1401-1415 (2016)Cited in2Mapped to33
Identifying the functional contribution of the defatty-acylase activity of SIRT6.Zhang X., Khan S., Jiang H., Antonyak M.A., Chen X., Spiegelman N.A., Shrimp J.H., Cerione R.A., Lin H.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Chem. Biol. 12:614-620 (2016)Cited in2Mapped to6
Insulin secretion impairment in Sirt6 knockout pancreatic beta cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway.Song M.Y., Wang J., Ka S.O., Bae E.J., Park B.H.View abstractCited forFUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF TYR-133CategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCSci. Rep. 6:30321-30321 (2016)Cited in2Mapped to6