P59823 · IRPL1_MOUSE

  • Protein
    Interleukin-1 receptor accessory protein-like 1
  • Gene
    Il1rapl1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity).
Plays a role in neurite outgrowth (By similarity).
During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:21940441, PubMed:25908590).

Catalytic activity

Features

Showing features for site, active site.

169550100150200250300350400450500550600650
TypeIDPosition(s)Description
Site34Essential for interaction with PTPRD
Active site490

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentcell surface
Cellular Componentcytoplasm
Cellular Componentdendrite
Cellular Componentglutamatergic synapse
Cellular Componentplasma membrane
Cellular Componentpostsynaptic density membrane
Cellular Componentpostsynaptic membrane
Molecular FunctionNAD+ nucleosidase activity
Molecular FunctionNAD+ nucleotidase, cyclic ADP-ribose generating
Molecular Functionsignaling receptor binding
Biological Processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processnegative regulation of exocytosis
Biological Processneuron differentiation
Biological Processpositive regulation of dendrite morphogenesis
Biological Processpositive regulation of dendritic spine morphogenesis
Biological Processpositive regulation of synapse assembly
Biological Processpresynaptic membrane assembly
Biological Processregulation of neuron projection development
Biological Processsignal transduction
Biological Processsynaptic membrane adhesion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interleukin-1 receptor accessory protein-like 1
  • EC number
  • Short names
    IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1
  • Alternative names
    • X-linked interleukin-1 receptor accessory protein-like 1

Gene names

    • Name
      Il1rapl1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P59823

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Cytoplasm
Cell projection, axon
Note: May localize to the cell body and growth cones of dendrite-like processes.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain25-357Extracellular
Transmembrane358-378Helical
Topological domain379-695Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis34Abolishes Interaction with PTPRD. Abolishes synaptogenesis.
Mutagenesis37Decreases affinity for PTPRD. Significantly decreases synaptogenesis.
Mutagenesis75-77Decreases affinity for PTPRD; when associated with 88-A--A-91. Significantly decreases synaptogenesis; when associated with 88-A--A-91.
Mutagenesis88-91Decreases affinity for PTPRD; when associated with 75-A--A-77. Significantly decreases synaptogenesis; when associated with 88-A--A-91.
Mutagenesis292Decreases affinity for PTPRD. Significantly decreases synaptogenesis.

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000001545525-695Interleukin-1 receptor accessory protein-like 1
Disulfide bond31↔126
Disulfide bond53↔118
Glycosylation63N-linked (GlcNAc...) asparagine
Glycosylation122N-linked (GlcNAc...) asparagine
Glycosylation138N-linked (GlcNAc...) asparagine
Disulfide bond143↔185
Disulfide bond164↔216
Glycosylation213N-linked (GlcNAc...) asparagine
Glycosylation264N-linked (GlcNAc...) asparagine
Disulfide bond267↔334
Glycosylation331N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in total brain extracts, olfactory bulb, hippocampus and striatum (at protein level).

Interaction

Subunit

Homodimer (PubMed:25908590).
Interacts (calcium-independent) with NCS1/FREQ (By similarity).
Interacts (via the first immunoglobilin domain) with PTPRD (via the second immunoglobilin domain); this interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation (PubMed:21940441, PubMed:25908590).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P59823Ptprd Q644876EBI-5452114, EBI-771834

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain25-134Ig-like C2-type 1
Domain143-232Ig-like C2-type 2
Domain242-350Ig-like C2-type 3
Domain403-558TIR
Region548-643Interaction with NCS1
Region657-679Disordered

Domain

The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

Sequence similarities

Belongs to the interleukin-1 receptor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    695
  • Mass (Da)
    79,630
  • Last updated
    2003-08-22 v1
  • Checksum
    5FE34F204E5908B7
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSVDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKAWRPSIVFKRDTLLIKEVKEDDIGNYTCELKYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTVQETQLGGSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLICSVTIYKCYKIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGNIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQKHYYRSYEYDVPPTGTLPLTSIGNQHTYCNIPMTLINGQRPQTKSNREPNPDEAHTNSAILPLLPRETSISSVIW

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
B1ASU0B1ASU0_MOUSEIl1rapl1696
Q0VDP7Q0VDP7_MOUSEIl1rapl1383

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL844900
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL672059
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AK081272
EMBL· GenBank· DDBJ
-mRNA No translation available.

Similar Proteins

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