P59822 · IL1AP_MACMU

Function

function

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity).
Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity).
Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).

Isoform 2

Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978).
Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site482

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular Functioninterleukin-1 receptor activity
Molecular Functioninterleukin-1 receptor binding
Molecular FunctionNAD+ nucleosidase activity
Molecular FunctionNAD+ nucleotidase, cyclic ADP-ribose generating
Biological Processinflammatory response
Biological Processpositive regulation of synapse assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interleukin-1 receptor accessory protein
  • EC number
  • Short names
    IL-1 receptor accessory protein; IL-1RAcP

Gene names

    • Name
      IL1RAP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    P59822

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain21-367Extracellular
Transmembrane368-388Helical
Topological domain389-570Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_000001545121-570Interleukin-1 receptor accessory protein
Disulfide bond24↔122
Disulfide bond47↔114
Glycosylation57N-linked (GlcNAc...) asparagine
Glycosylation107N-linked (GlcNAc...) asparagine
Glycosylation111N-linked (GlcNAc...) asparagine
Glycosylation118N-linked (GlcNAc...) asparagine
Disulfide bond137↔181
Disulfide bond160↔212
Glycosylation196N-linked (GlcNAc...) asparagine
Glycosylation209N-linked (GlcNAc...) asparagine
Disulfide bond266↔332
Glycosylation299N-linked (GlcNAc...) asparagine
Modified residue557Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity).
The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain21-128Ig-like C2-type 1
Region69-85Essential for interaction with PTPRD
Domain136-226Ig-like C2-type 2
Domain242-350Ig-like C2-type 3
Domain403-546TIR
Region549-570Disordered

Domain

The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

Sequence similarities

Belongs to the interleukin-1 receptor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

P59822-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Membrane-bound IL-1R AcP
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    570
  • Mass (Da)
    65,393
  • Last updated
    2003-08-22 v1
  • Checksum
    9CD78AB1E78DD4C5
MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIAFISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDIPIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAATVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASQGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV

P59822-2

  • Name
    2
  • Synonyms
    Soluble IL-1R AcP
  • See also
    sequence in UniParc or sequence clusters in UniRef

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F7ZKD4A0A5F7ZKD4_MACMUIL1RAP536
F6ZL12F6ZL12_MACMUIL1RAP687
A0A1I7Q486A0A1I7Q486_MACMUIL1RAP641

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY182233
EMBL· GenBank· DDBJ
AAO24704.1
EMBL· GenBank· DDBJ
mRNA
AY182234
EMBL· GenBank· DDBJ
AAO24705.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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