P59822 · IL1AP_MACMU
- ProteinInterleukin-1 receptor accessory protein
- GeneIL1RAP
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids570 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity).
Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity).
Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).
Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity).
Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).
Isoform 2
Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978).
Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
Catalytic activity
- NAD+ + H2O = ADP-D-ribose + nicotinamide + H+This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 482 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Molecular Function | interleukin-1 receptor activity | |
Molecular Function | interleukin-1 receptor binding | |
Molecular Function | NAD+ nucleosidase activity | |
Molecular Function | NAD+ nucleotidase, cyclic ADP-ribose generating | |
Biological Process | inflammatory response | |
Biological Process | positive regulation of synapse assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInterleukin-1 receptor accessory protein
- EC number
- Short namesIL-1 receptor accessory protein; IL-1RAcP
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionP59822
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Isoform 1
Cell membrane ; Single-pass type I membrane protein
Isoform 2
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 21-367 | Extracellular | |||
Transmembrane | 368-388 | Helical | |||
Topological domain | 389-570 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_0000015451 | 21-570 | Interleukin-1 receptor accessory protein | ||
Disulfide bond | 24↔122 | ||||
Disulfide bond | 47↔114 | ||||
Glycosylation | 57 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 107 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 111 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 118 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 137↔181 | ||||
Disulfide bond | 160↔212 | ||||
Glycosylation | 196 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 209 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 266↔332 | ||||
Glycosylation | 299 | N-linked (GlcNAc...) asparagine | |||
Modified residue | 557 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity).
The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).
The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 21-128 | Ig-like C2-type 1 | |||
Region | 69-85 | Essential for interaction with PTPRD | |||
Domain | 136-226 | Ig-like C2-type 2 | |||
Domain | 242-350 | Ig-like C2-type 3 | |||
Domain | 403-546 | TIR | |||
Region | 549-570 | Disordered | |||
Domain
The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence similarities
Belongs to the interleukin-1 receptor family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
P59822-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsMembrane-bound IL-1R AcP
- Length570
- Mass (Da)65,393
- Last updated2003-08-22 v1
- Checksum9CD78AB1E78DD4C5
P59822-2
- Name2
- SynonymsSoluble IL-1R AcP
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F7ZKD4 | A0A5F7ZKD4_MACMU | IL1RAP | 536 | ||
F6ZL12 | F6ZL12_MACMU | IL1RAP | 687 | ||
A0A1I7Q486 | A0A1I7Q486_MACMU | IL1RAP | 641 |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY182233 EMBL· GenBank· DDBJ | AAO24704.1 EMBL· GenBank· DDBJ | mRNA | ||
AY182234 EMBL· GenBank· DDBJ | AAO24705.1 EMBL· GenBank· DDBJ | mRNA |