P59637 · VEMP_SARS
- ProteinEnvelope small membrane protein
- GeneE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity).
Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction
Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | host cell endoplasmic reticulum-Golgi intermediate compartment | |
Cellular Component | host cell Golgi apparatus | |
Cellular Component | host cell Golgi membrane | |
Cellular Component | membrane | |
Cellular Component | virion membrane | |
Molecular Function | identical protein binding | |
Biological Process | apoptotic process | |
Biological Process | disruption of plasma membrane integrity in another organism | |
Biological Process | viral budding from Golgi membrane |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEnvelope small membrane protein
- Short namesE protein ; sM protein
Gene names
Organism names
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Sarbecovirus
- Virus hosts
Accessions
- Primary accessionP59637
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Host Golgi apparatus membrane ; Single-pass type III membrane protein
Note: Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment (PubMed:20861307).
The cytoplasmic tail functions as a Golgi complex-targeting signal
The cytoplasmic tail functions as a Golgi complex-targeting signal
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-16 | Virion surface | ||||
Sequence: MYSFVSEETGTLIVNS | ||||||
Transmembrane | 17-37 | Helical | ||||
Sequence: VLLFLAFVVFLLVTLAILTAL | ||||||
Topological domain | 38-76 | Intravirion | ||||
Sequence: RLCAYCCNIVNVSLVKPTVYVYSRVKNLNSSEGVPDLLV |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 24 | in strain: Isolate GD01 | ||||
Sequence: V → M | ||||||
Mutagenesis | 73-76 | Abolishes interaction with PDZ domain of human PALS1; loss of accumulation in host perinuclear compartment. | ||||
Sequence: Missing |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000106074 | 1-76 | Envelope small membrane protein | |||
Sequence: MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPTVYVYSRVKNLNSSEGVPDLLV |
Interaction
Subunit
Homopentamer (PubMed:22819936).
Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex (PubMed:19322648).
Interacts with Nucleoprotein (PubMed:24766657).
Interacts with the accessory proteins 3a and 7a. Interacts (via C-terminus) with human PALS1 (via PDZ domain); this inhibits the interaction between human PALS1 and human CRB3, and causes delayed tight junction formation and defective cell polarity (PubMed:20861307).
Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex (PubMed:19322648).
Interacts with Nucleoprotein (PubMed:24766657).
Interacts with the accessory proteins 3a and 7a. Interacts (via C-terminus) with human PALS1 (via PDZ domain); this inhibits the interaction between human PALS1 and human CRB3, and causes delayed tight junction formation and defective cell polarity (PubMed:20861307).
Binary interactions
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 73-76 | PDZ-binding; required for interaction with human PALS1 | ||||
Sequence: DLLV |
Sequence similarities
Belongs to the betacoronaviruses E protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length76
- Mass (Da)8,361
- Last updated2003-04-23 v1
- ChecksumA6D9A31652DDA194
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY278741 EMBL· GenBank· DDBJ | AAP13443.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY274119 EMBL· GenBank· DDBJ | AAP41040.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY304492 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY282752 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY278554 EMBL· GenBank· DDBJ | AAP13570.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY278491 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY283794 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY283795 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY283796 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY283797 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY283798 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY278487 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY278488 EMBL· GenBank· DDBJ | AAP30033.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY278489 EMBL· GenBank· DDBJ | AAP51230.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY278490 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY279354 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY291451 EMBL· GenBank· DDBJ | AAP37020.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY310120 EMBL· GenBank· DDBJ | AAP50488.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY291315 EMBL· GenBank· DDBJ | AAP33700.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY297028 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY323975 EMBL· GenBank· DDBJ | AAP73416.1 EMBL· GenBank· DDBJ | mRNA | ||
AY321118 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY463059 EMBL· GenBank· DDBJ | AAP82979.2 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY338174 EMBL· GenBank· DDBJ | AAQ01600.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY338175 EMBL· GenBank· DDBJ | AAQ01612.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY348314 EMBL· GenBank· DDBJ | AAP97885.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AP006557 EMBL· GenBank· DDBJ | BAC81351.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AP006558 EMBL· GenBank· DDBJ | BAC81365.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AP006559 EMBL· GenBank· DDBJ | BAC81379.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AP006560 EMBL· GenBank· DDBJ | BAC81393.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AP006561 EMBL· GenBank· DDBJ | BAC81407.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY323977 EMBL· GenBank· DDBJ | AAP72977.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AY362698 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY362699 EMBL· GenBank· DDBJ | - | Genomic RNA | No translation available. | |
AY427439 EMBL· GenBank· DDBJ | AAQ94063.1 EMBL· GenBank· DDBJ | Genomic RNA |