P59259 · H4_ARATH
- ProteinHistone H4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids103 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 17-21 | |||||
Sequence: KRHRK |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chloroplast | |
Cellular Component | cytosol | |
Cellular Component | extracellular region | |
Cellular Component | nucleolus | |
Cellular Component | nucleosome | |
Cellular Component | peroxisome | |
Cellular Component | plant-type vacuole | |
Cellular Component | plasma membrane | |
Cellular Component | plasmodesma | |
Cellular Component | plastid | |
Cellular Component | thylakoid | |
Molecular Function | DNA binding | |
Molecular Function | protein heterodimerization activity | |
Molecular Function | structural constituent of chromatin | |
Biological Process | response to water deprivation |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameHistone H4
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP59259
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000158278 | 1-103 | Histone H4 | |||
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDAVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGG |
Post-translational modification
May be acetylated by MBD9.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with ORTH2 (PubMed:17242155).
Interacts with AHL27 (PubMed:24218605).
Interacts with AHL27 (PubMed:24218605).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MSGRGKGGKGLGKGGAKRHR |
Sequence similarities
Belongs to the histone H4 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
P59259-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length103
- Mass (Da)11,409
- Last updated2007-01-23 v2
- ChecksumA9FD57725A2A7598
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A8MRV1 | A8MRV1_ARATH | At1g07660 | 86 |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M17132 EMBL· GenBank· DDBJ | AAA32810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M17133 EMBL· GenBank· DDBJ | AAA32811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC007583 EMBL· GenBank· DDBJ | AAF75089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC007583 EMBL· GenBank· DDBJ | AAF75072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC005727 EMBL· GenBank· DDBJ | AAC79580.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC007184 EMBL· GenBank· DDBJ | AAM15445.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL162459 EMBL· GenBank· DDBJ | CAB82817.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL133298 EMBL· GenBank· DDBJ | CAB62023.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL132960 EMBL· GenBank· DDBJ | CAB88335.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB006705 EMBL· GenBank· DDBJ | BAB09507.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB015475 EMBL· GenBank· DDBJ | BAB08365.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE28158.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE28187.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE28188.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC08165.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE78091.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE78146.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE79133.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED97220.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED97260.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | ANM70482.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF325058 EMBL· GenBank· DDBJ | AAG40410.1 EMBL· GenBank· DDBJ | mRNA | ||
AF334729 EMBL· GenBank· DDBJ | AAG50107.1 EMBL· GenBank· DDBJ | mRNA | ||
AY057609 EMBL· GenBank· DDBJ | AAL14404.1 EMBL· GenBank· DDBJ | mRNA | ||
AY062717 EMBL· GenBank· DDBJ | AAL32795.1 EMBL· GenBank· DDBJ | mRNA | ||
AY063857 EMBL· GenBank· DDBJ | AAL36213.1 EMBL· GenBank· DDBJ | mRNA | ||
AY093353 EMBL· GenBank· DDBJ | AAM13352.1 EMBL· GenBank· DDBJ | mRNA | ||
AY099675 EMBL· GenBank· DDBJ | AAM20526.1 EMBL· GenBank· DDBJ | mRNA | ||
AY124836 EMBL· GenBank· DDBJ | AAM70545.1 EMBL· GenBank· DDBJ | mRNA | ||
AY128855 EMBL· GenBank· DDBJ | AAM91255.1 EMBL· GenBank· DDBJ | mRNA | ||
AY142651 EMBL· GenBank· DDBJ | AAN13189.1 EMBL· GenBank· DDBJ | mRNA | ||
AY085175 EMBL· GenBank· DDBJ | AAM61726.1 EMBL· GenBank· DDBJ | mRNA | ||
AY085495 EMBL· GenBank· DDBJ | AAM62721.1 EMBL· GenBank· DDBJ | mRNA | ||
AY085965 EMBL· GenBank· DDBJ | AAM63175.1 EMBL· GenBank· DDBJ | mRNA | ||
AY086789 EMBL· GenBank· DDBJ | AAM63839.1 EMBL· GenBank· DDBJ | mRNA | ||
AY086185 EMBL· GenBank· DDBJ | AAM64264.1 EMBL· GenBank· DDBJ | mRNA | ||
AY087061 EMBL· GenBank· DDBJ | AAM64622.1 EMBL· GenBank· DDBJ | mRNA | ||
AY087188 EMBL· GenBank· DDBJ | AAM64744.1 EMBL· GenBank· DDBJ | mRNA |